ArticleMolecular brain2012
mGluR₁,5 activation improves network asynchrony and GABAergic synapse attenuation in the amygdala: implication for anxiety-like behavior in DBA/2 mice.
Article in Molecular brain, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 53 citations in OpenAlex.
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- Novel behavioral tasks for the measurement of social motivation in mice: a comparison across strains.Frontiers in behavioral neuroscience · 2025Article
- Associative memory cells of encoding fear signals and anxiety are recruited by neuroligin-3-mediated synapse formation.Communications biology · 2024Article
- Developmentally Regulated Modulation of Lumbar Motoneurons by Metabotropic Glutamate Receptors: A Cellular and Behavioral Analysis in Newborn Mice.Frontiers in cellular neuroscience · 2021Article
- microRNA-15b contributes to depression-like behavior in mice by affecting synaptic protein levels and function in the nucleus accumbens.The Journal of biological chemistry · 2020Article
- [Effects of olfactory deprivation on action potential and ankyrin-G expression in glutamatergic neurons in the barrel cortex of mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- microRNA and mRNA profiles in the amygdala are associated with stress-induced depression and resilience in juvenile mice.Psychopharmacology · 2019Article
- Searching basic units in memory traces: associative memory cells.F1000Research · 2019Review
- Cell-specific plasticity associated with integrative memory of triple sensory signals in the barrel cortex.Oncotarget · 2018Article
- Activity strengths of cortical glutamatergic and GABAergic neurons are correlated with transgenerational inheritance of learning ability.Oncotarget · 2017Article
- Piriform cortical glutamatergic and GABAergic neurons express coordinated plasticity for whisker-induced odor recall.Oncotarget · 2017Article
- Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum.Oncotarget · 2017Article
- PKC and CaMK-II inhibitions coordinately rescue ischemia-induced GABAergic neuron dysfunction.Oncotarget · 2017Article
- GABAergic neurons in nucleus accumbens are correlated to resilience and vulnerability to chronic stress for major depression.Oncotarget · 2017Article
- Activity-induced spontaneous spikes in GABAergic neurons suppress seizure discharges: an implication of computational modeling.Oncotarget · 2017Article
- Coordinated Plasticity among Glutamatergic and GABAergic Neurons and Synapses in the Barrel Cortex Is Correlated to Learning Efficiency.Frontiers in cellular neuroscience · 2017Article
- Synapse Innervation and Associative Memory Cell Are Recruited for Integrative Storage of Whisker and Odor Signals in the Barrel Cortex through miRNA-Mediated Processes.Frontiers in cellular neuroscience · 2017Article
- Associative Memory Extinction Is Accompanied by Decayed Plasticity at Motor Cortical Neurons and Persistent Plasticity at Sensory Cortical Neurons.Frontiers in cellular neuroscience · 2017Article
- Negative Affect and Excessive Alcohol Intake Incubate during Protracted Withdrawal from Binge-Drinking in Adolescent, But Not Adult, Mice.Frontiers in psychology · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Anxiety is a prevalent psychological disorder, in which the atypical expression of certain genes and the abnormality of amygdala are involved. Intermediate processes between genetic defects and anxiety, pathophysiological characteristics of neural network, remain unclear. Using behavioral task, two-photon cellular imaging and electrophysiology, we studied the characteristics of neural networks in basolateral amygdala and the influences of metabotropic glutamate receptor (mGluR) on their dynamics in DBA/2 mice showing anxiety-related genetic defects. Amygdala neurons in DBA/2 high anxiety mice express asynchronous activity and diverse excitability, and their GABAergic synapses demonstrate weak transmission, compared to those in low anxiety FVB/N mice. mGluR1,5 activation improves the anxiety-like behaviors of DBA/2 mice, synchronizes the activity of amygdala neurons and strengthens the transmission of GABAergic synapses. The activity asynchrony of amygdala neurons and the weakness of GABA synaptic transmission are associated with anxiety-like behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.