ArticleBMC cancer2012
Snake venom toxin from Vipera lebetina turanica induces apoptosis of colon cancer cells via upregulation of ROS- and JNK-mediated death receptor expression.
Article in BMC cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- Alleviation of viper venom induced platelet apoptosis by crocin (Crocus sativus): implications for thrombocytopenia in viper bites.Journal of thrombosis and thrombolysis · 2013Trial
- Evodiamine Inhibits Colorectal Cancer by Downregulating ASS1 via Wnt/β-Catenin/c-MYC Pathway to Block Arginine Synthesis.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Anticancer potency of Egyptian venom snakes on MCF-7 and HepG2 carcinoma cells.Environmental analysis, health and toxicology · 2024Article
- Bibliometric Analysis of Literature in Snake Venom-Related Research Worldwide (1933-2022).Animals : an open access journal from MDPI · 2022Article
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- Investigations on the Changes of Serum Proteins in Rabbits afterEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Targeting TGF-β-Mediated SMAD Signaling Pathway via Novel Recombinant Cytotoxin II: A Potent Protein fromMolecules (Basel, Switzerland) · 2020Article
- Review
- Anticancer and antibacterial effects of Iranian viper (Vipera latifii) venom; an in-vitro study.Journal of cellular physiology · 2018Article
- Scorpion Venom Causes Upregulation of p53 and Downregulation of Bcl-xIntegrative cancer therapies · 2018Article
- Morphometric characteristics and seasonal proximity to water of the Cypriot blunt-nosed viperThe journal of venomous animals and toxins including tropical diseases · 2018Article
- Functional chlorin gold nanorods enable to treat breast cancer by photothermal/photodynamic therapy.International journal of nanomedicine · 2018Article
- Article
- Curcumin derivative WZ35 efficiently suppresses colon cancer progression through inducing ROS production and ER stress-dependent apoptosis.American journal of cancer research · 2017Article
- Article
- Propensity of crocin to offset Vipera russelli venom induced oxidative stress mediated neutrophil apoptosis: a biochemical insight.Cytotechnology · 2016Article
- Article
- Snake venom causes apoptosis by increasing the reactive oxygen species in colorectal and breast cancer cell lines.OncoTargets and therapy · 2016Article
- Anticancer Activity a of Caspian Cobra (Iranian journal of pharmaceutical research : IJPR · 2016Article
- Cytotoxic activity ofThe journal of venomous animals and toxins including tropical diseases · 2016Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbundant research suggested that the cancer cells avoid destruction by the immune system through down-regulation or mutation of death receptors. Therefore, it is very important that finding the agents that increase the death receptors of cancer cells. In this study, we demonstrated that the snake venom toxin from Vipera lebetina turanica induce the apoptosis of colon cancer cells through reactive oxygen species (ROS) and c-Jun N-terminal kinases (JNK) dependent death receptor (DR4 and DR5) expression.
methodsWe used cell viability assays, DAPI/TUNEL assays, as well as western blot for detection of apoptosis related proteins and DRs to demonstrate that snake venom toxin-induced apoptosis is DR4 and DR5 dependent. We carried out transient siRNA knockdowns of DR4 and DR5 in colon cancer cells.
resultsWe showed that snake venom toxin inhibited growth of colon cancer cells through induction of apoptosis. We also showed that the expression of DR4 and DR5 was increased by treatment of snake venom toxin. Moreover, knockdown of DR4 or DR5 reversed the effect of snake venom toxin. Snake venom toxin also induced JNK phosphorylation and ROS generation, however, pretreatment of JNK inhibitor and ROS scavenger reversed the inhibitory effect of snake venom toxin on cancer cell proliferation, and reduced the snake venom toxin-induced upregulation of DR4 and DR5 expression.
conclusionsOur results indicated that snake venom toxin could inhibit human colon cancer cell growth, and these effects may be related to ROS and JNK mediated activation of death receptor (DR4 and DR5) signals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.