ArticleActa psychiatrica Scandinavica2012
C-reactive protein, early life stress, and wellbeing in healthy adults.
Article in Acta psychiatrica Scandinavica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- The association of child maltreatment and systemic inflammation in adulthood: A systematic review.PloS one · 2021Pooled it
- Replication and reproducibility issues in the relationship between C-reactive protein and depression: A systematic review and focused meta-analysis.Brain, behavior, and immunity · 2018Pooled it
- Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α.Molecular psychiatry · 2016Pooled it
- Association of trauma exposure with proinflammatory activity: a transdiagnostic meta-analysis.Translational psychiatry · 2014Pooled it
- Article
- Concurrent associations between objective markers and subjective markers of aging with indicators of successful aging: An integrative approach.European journal of ageing · 2026Article
- School Segregation and Health Across Racial Groups: A Life Course Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2024Article
- Inflammatory burden of adolescents with childhood maltreatment: results from baseline data of a school cohort.European child & adolescent psychiatry · 2024Article
- Student Debt and Cardiovascular Disease Risk Among U.S. Adults in Early Mid-Life.American journal of preventive medicine · 2022Article
- Lower Life Satisfaction and Inflammation in African American Adults: Body Adiposity Mediation and Sex Moderation.Journal of personalized medicine · 2022Article
- Associations Between Parental Mood and Anxiety Psychopathology and Offspring Brain Structure: A Scoping Review.Clinical child and family psychology review · 2022Article
- Effects of Subtypes of Child Maltreatment on CRP in Adulthood.Frontiers in psychiatry · 2021Article
- Epigenetic differences in inflammation genes of monozygotic twins are related to parent-child emotional availability and health.Brain, behavior, & immunity - health · 2020Article
- Longitudinal changes of inflammatory biomarkers moderate the relationship between recent stressful life events and prospective symptoms of depression in a diverse sample of urban adolescents.Brain, behavior, and immunity · 2020Article
- The Impact of Educational Attainment on Black Women's Obesity Rate in the United States.Journal of racial and ethnic health disparities · 2020Article
- Potential Health Implications and Health Cost Reductions of Transit-Induced Physical Activity.Journal of transport & health · 2016Article
- Adversity in preschool-aged children: Effects on salivary interleukin-1β.Development and psychopathology · 2015Article
- From stress to inflammation and major depressive disorder: a social signal transduction theory of depression.Psychological bulletin · 2014Review
- Association of elevated cytokines with childhood adversity in a sample of healthy adults.Journal of psychiatric research · 2013Article
- Psychological Stress During Childhood and Adolescence and Its Association With Inflammation Across the Lifespan: A Critical Review and Meta-Analysis.Psychological bulletinArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine whether C-reactive protein (CRP) can serve as a marker for alterations in immune function prior to the manifestation of significant psychiatric and medical disorders.
methodNinety-two healthy adults were recruited from the community and determined to be free of psychiatric or medical disorders. The concentration of plasma CRP from a single resting sample was examined in relation to current mental and physical health as well as to self-reported history of early life adversity.
resultsC-reactive protein showed a significant positive correlation with body mass index (BMI; r = 0.477, P < 0.001). Non-specific pain, fatigue, and lower overall quality of physical health were all associated with higher CRP concentrations (all P < 0.05 or P < 0.01), after controlling for effect of BMI and other relevant covariates. Subthreshold depression symptoms and other indices of mental/emotional wellbeing were not associated with CRP, nor was CRP significantly linked to any measures of early life adversity.
conclusionLower-quality physical health and wellbeing, but not the presence of mood/anxiety symptoms or early life stress (ELS), were significantly related to plasma CRP. Elevated CRP does not appear to be a fundamental consequence of ELS among healthy adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.