ArticlePhysical review letters2012
Coupling between switching regulation and torque generation in bacterial flagellar motor.
Article in Physical review letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Signature of cooperativity in the stochastic fluctuations of small systems with application to the bacterial flagellar motor.Scientific reports · 2025Article
- Structure and Dynamics of the Bacterial Flagellar Motor Complex.Biomolecules · 2024Review
- Bacterial Proprioception: Can a Bacterium Sense Its Movement?Frontiers in microbiology · 2022Review
- Bacterial Vivisection: How Fluorescence-Based Imaging Techniques Shed a Light on the Inner Workings of Bacteria.Microbiology and molecular biology reviews : MMBR · 2020Review
- The Architectural Dynamics of the Bacterial Flagellar Motor Switch.Biomolecules · 2020Review
- High pressure inhibits signaling protein binding to the flagellar motor and bacterial chemotaxis through enhanced hydration.Scientific reports · 2020Article
- Flagella-Driven Motility of Bacteria.Biomolecules · 2019Review
- Directional Switching Mechanism of the Bacterial Flagellar Motor.Computational and structural biotechnology journal · 2019Review
- Spatial arrangement of several flagellins within bacterial flagella improves motility in different environments.Nature communications · 2018Article
- Frequent pauses in Escherichia coli flagella elongation revealed by single cell real-time fluorescence imaging.Nature communications · 2018Article
- Transient locking of the hook procures enhanced motility to flagellated bacteria.Scientific reports · 2017Article
- Impact of fluorescent protein fusions on the bacterial flagellar motor.Scientific reports · 2017Article
- Bacterial Flagellar Motor Switch in Response to CheY-P Regulation and Motor Structural Alterations.Biophysical journal · 2016Article
- A Delicate Nanoscale Motor Made by Nature-The Bacterial Flagellar Motor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2015Article
- Mechanics of torque generation in the bacterial flagellar motor.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Structure and function of the bi-directional bacterial flagellar motor.Biomolecules · 2014Review
- Populational heterogeneity vs. temporal fluctuation in Escherichia coli flagellar motor switching.Biophysical journal · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The bacterial flagellar motor plays a crucial role in both bacterial locomotion and chemotaxis. Recent experiments reveal that the switching dynamics of the motor depend on the rotation speed of the motor, and thus the motor torque, nonmonotonically. Here we present a unified mathematical model which treats motor torque generation based on experimental torque-speed curves and the torque-dependent switching based on the conformational spread model. The model successfully reproduces the observed switching rate as a function of the rotation speed, and provides a generic physical explanation independent of most details. A stator affects the switching dynamics through two mechanisms: accelerating the conformational flipping rate of individual rotor-switching units, which contributes most when the stator works at a high torque and thus a low speed; and influencing a larger number of rotor-switching units within unit time, whose contribution is the greatest when the motor rotates at a high speed. Consequently, the switching rate shows a maximum at intermediate speed, where the above two mechanisms find an optimal output. The load-switching relation may serve as a mechanism for sensing the physical environment, similar to the chemotaxis mechanism for sensing the chemical environment. It may also coordinate the switch dynamics of motors within the same cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.