ArticleAmerican journal of cancer research2012
Inflammation in thyroid oncogenesis.
Article in American journal of cancer research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Hashimoto's thyroiditis reduces central lymph node metastasis risk in papillary thyroid microcarcinoma: an integrated meta-analysis.Frontiers in endocrinology · 2025Pooled it
- The Role of Mean Platelet Volume (MPV) in Thyroid Cancers: A Scoping Review.Medicina (Kaunas, Lithuania) · 2026Review
- The Occurrence of Gene Fusions in Thyroid Lesions and the Relation With Chronic Lymphocytic Thyroiditis.Pathology international · 2026Article
- Long-term risk of incident thyroid cancer after COVID-19 in patients with thyroid disorder: a multicenter propensity score-matched cohort study.Frontiers in endocrinology · 2026Article
- Prognosis of differentiated thyroid cancer in patients with Graves' disease: a meta-analysis.Thyroid research · 2025Review
- TGF-β induces EMT in thyroid cancer cells by regulating transcription factors.Thyroid research · 2025Article
- Circular RNAs in cancer.MedComm · 2025Review
- Amyloid Goiter, Papillary Thyroid Carcinoma, and Diffuse Thyroid Lipomatosis: A Case Report of a Rare Association.Cureus · 2024Article
- Genetic and Epigenetic Association ofInternational journal of molecular sciences · 2024Article
- Role of Mediterranean diet in endocrine diseases: a joint overview by the endocrinologist and the nutritionist.Journal of endocrinological investigation · 2024Review
- Tumor Inflammatory Microenvironment of the Thyroid Cancer: Relationship between Regulatory T-Cell Imbalance, and p-NFΚB (p65) Expression-A Preliminary Study.Journal of clinical medicine · 2023Article
- Comprehensive analysis of BTNL9 as a prognostic biomarker correlated with immune infiltrations in thyroid cancer.BMC medical genomics · 2023Article
- Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules?Medicina (Kaunas, Lithuania) · 2023Article
- The role of Graves' disease in the development of thyroid nodules and thyroid cancer.European thyroid journal · 2023Observational
- Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis.Molecular cancer · 2023Article
- Systematic analysis of the prognosis and immune infiltration of E2Fs in thyroid carcinoma.Frontiers in genetics · 2023Article
- Identifying and analyzing the key genes shared by papillary thyroid carcinoma and Hashimoto's thyroiditis using bioinformatics methods.Frontiers in endocrinology · 2023Article
- The Obscure Potential of AHNAK2.Cancers · 2022Review
- MMP1 acts as a potential regulator of tumor progression and dedifferentiation in papillary thyroid cancer.Frontiers in oncology · 2022Article
- Diagnostic and prognostic value of tumor-infiltrating B cells in lymph node metastases of papillary thyroid carcinoma.Virchows Archiv : an international journal of pathology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is commonly accepted that cancer is linked to inflammation. The possible mechanisms by which inflammation can contribute to carcinogenesis include induction of genomic instability, alterations in epigenetic events and subsequent inappropriate gene expression, enhanced proliferation of initiated cells, resistance to apoptosis, aggressive tumor neovascularization, invasion through tumor-associated basement membrane and metastasis. Inflammation also affects immune surveillance and responses to therapy. In this review, we overview the current understanding of different aspects of thyroid cancer and inflammation. Several studies have strongly suggested an increased risk of PTC in patients with Hashimoto's thyroiditis (HT), the most common autoimmune disease in thyroid cancer. Furthermore, an intense immune infiltrate is often associated with papillary thyroid carcinoma (PTC), and might play a critical role in the regulation of carcinogenesis and in carcinoma progression. The characterization of the most relevant inflammatory pathways of cancer-related inflammation (CRI) is instrumental for the identification of new target molecules that could lead to improved diagnosis and treatment.
Indexed as
Identifiers
22679559PMC3365810W1607111379What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.