ArticleScientific reports2012
Incunabular immunological events in prion trafficking.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Acute LPS exposure enhances susceptibility to peripheral prion infection.Scientific reports · 2025Article
- Innate Immune Mechanisms in the Central Nervous System.Advances in experimental medicine and biology · 2025Review
- Role of sialylation of N-linked glycans in prion pathogenesis.Cell and tissue research · 2023Review
- The role of microglia in prion diseases and possible therapeutic targets: a literature review.Prion · 2021Review
- Host prion protein expression levels impact prion tropism for the spleen.PLoS pathogens · 2020Article
- Infectious Diseases and the Lymphoid Extracellular Matrix Remodeling: A Focus on Conduit System.Cells · 2020Review
- Unaltered intravenous prion disease pathogenesis in the temporary absence of marginal zone B cells.Scientific reports · 2019Article
- Prion Strain-Specific Structure and Pathology: A View from the Perspective of Glycobiology.Viruses · 2018Review
- Complement Regulatory Protein Factor H Is a Soluble Prion Receptor That Potentiates Peripheral Prion Pathogenesis.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- How do PrPPathogens (Basel, Switzerland) · 2017Review
- Oral Prion Disease Pathogenesis Is Impeded in the Specific Absence of CXCR5-Expressing Dendritic Cells.Journal of virology · 2017Article
- Sialylation Controls Prion FateThe Journal of biological chemistry · 2017Article
- PrPC expression and prion seeding activity in the alimentary tract and lymphoid tissue of deer.PloS one · 2017Article
- Article
- Clay Components in Soil Dictate Environmental Stability and Bioavailability of Cervid Prions in Mice.Frontiers in microbiology · 2016Article
- Multifaceted Role of Sialylation in Prion Diseases.Frontiers in neuroscience · 2016Review
- Post-conversion sialylation of prions in lymphoid tissues.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Prions--not your immunologist's pathogen.PLoS pathogens · 2015Review
- Emerging and Novel Functions of Complement Protein C1q.Frontiers in immunology · 2015Review
- The Good, the Bad, and the Ugly of Dendritic Cells during Prion Disease.Journal of immunology research · 2015Review
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Authors and funding
11 authors.
Funding
Abstract
While prions probably interact with the innate immune system immediately following infection, little is known about this initial confrontation. Here we investigated incunabular events in lymphotropic and intranodal prion trafficking by following highly enriched, fluorescent prions from infection sites to draining lymph nodes. We detected biphasic lymphotropic transport of prions from the initial entry site upon peripheral prion inoculation. Prions arrived in draining lymph nodes cell autonomously within two hours of intraperitoneal administration. Monocytes and dendritic cells (DCs) required Complement for optimal prion delivery to lymph nodes hours later in a second wave of prion trafficking. B cells constituted the majority of prion-bearing cells in the mediastinal lymph node by six hours, indicating intranodal prion reception from resident DCs or subcapsulary sinus macrophages or directly from follicular conduits. These data reveal novel, cell autonomous prion lymphotropism, and a prominent role for B cells in intranodal prion movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.