ArticleFrontiers in neural circuits2012
Cortical nNOS neurons co-express the NK1 receptor and are depolarized by Substance P in multiple mammalian species.
Article in Frontiers in neural circuits, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Decoding Brain Development and Function Through GABAergic Inhibitory Neurons.The European journal of neuroscience · 2026Review
- Substance P regulates Tacr1 neurons, which control nitric oxide-mediated neurovascular coupling in the mouse cortex.Science advances · 2026Article
- From peripheral initiation to central integration: a narrative review of the antihypertensive mechanisms of acupuncture in regulating autonomic nervous system homeostasis.Frontiers in neuroscience · 2026Review
- Article
- Article
- Type-I nNOS neurons orchestrate cortical neural activity and vasomotion.bioRxiv : the preprint server for biology · 2025Article
- Mediation Effect of CSF Substance P on the Association Between Smoking and Sleep.Brain and behavior · 2025Article
- Parvalbumin interneuron activity induces slow cerebrovascular fluctuations in awake mice.bioRxiv : the preprint server for biology · 2024Article
- Long-range inhibitory neurons mediate cortical neurovascular coupling.Cell reports · 2024Article
- Intrinsic organization of the corpus callosum.Frontiers in physiology · 2024Review
- Parvalbumin interneuron activity drives fast inhibition-induced vasoconstriction followed by slow substance P-mediated vasodilation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Neurovascular coupling: motive unknown.Trends in neurosciences · 2022Review
- Organization of Cortical and Thalamic Input to Inhibitory Neurons in Mouse Motor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Article
- Poster Viewing Sessions PB01-B01 to PB03-V09.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Excitation of Cortical nNOS/NK1R Neurons by Hypocretin 1 is Independent of Sleep Homeostasis.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- The potential of substance P to initiate and perpetuate cortical spreading depression (CSD) in rat in vivo.Scientific reports · 2018Article
- Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We have previously demonstrated that Type I neuronal nitric oxide synthase (nNOS)-expressing neurons are sleep-active in the cortex of mice, rats, and hamsters. These neurons are known to be GABAergic, to express Neuropeptide Y (NPY) and, in rats, to co-express the Substance P (SP) receptor NK1, suggesting a possible role for SP in sleep/wake regulation. To evaluate the degree of co-expression of nNOS and NK1 in the cortex among mammals, we used double immunofluorescence for nNOS and NK1 and determined the anatomical distribution in mouse, rat, and squirrel monkey cortex. Type I nNOS neurons co-expressed NK1 in all three species although the anatomical distribution within the cortex was species-specific. We then performed in vitro patch clamp recordings in cortical neurons in mouse and rat slices using the SP conjugate tetramethylrhodamine-SP (TMR-SP) to identify NK1-expressing cells and evaluated the effects of SP on these neurons. Bath application of SP (0.03-1 μM) resulted in a sustained increase in firing rate of these neurons; depolarization persisted in the presence of tetrodotoxin. These results suggest a conserved role for SP in the regulation of cortical sleep-active neurons in mammals.
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