Evidence map›Paper›PMID 22679339›Full record

ArticleJournal of the Royal Statistical Society. Series C, Applied statistics2012

Longitudinal Penalized Functional Regression for Cognitive Outcomes on Neuronal Tract Measurements.

Jeff Goldsmith, Ciprian M Crainiceanu, Brian Caffo, Daniel Reich

Abstract read
In one paragraph

Article in Journal of the Royal Statistical Society. Series C, Applied statistics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Quantile Regression for Longitudinal Functional Data with Application to Feed Intake of Lactating Sows.Journal of agricultural, biological, and environmental statistics · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Extreme quantile estimation for partial functional linear regression models with heavy-tailed distributions.The Canadian journal of statistics = Revue canadienne de statistique · 2022
    Article
  11. Fast Univariate Inference for Longitudinal Functional Models.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Additive Functional Cox Model.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2021
    Article
  18. Article
  19. Review
  20. Longitudinal dynamic functional regression.Journal of the Royal Statistical Society. Series C, Applied statistics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jeff Goldsmith
Ciprian M Crainiceanu
Brian Caffo
Daniel Reich

Funding

Multimodal MRI in Multiple SclerosisZIANS003119 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI REICH, DANIEL · 2010 to 2025
$53.4M
Statistical Methods for Multilevel Multivariate Functional StudiesR01NS060910 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Ciprian M Crainiceanu · 2009 to 2026
$8.3M
Statistical methods for large n and p problemsR01EB012547 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI CAFFO, BRIAN SCOTT · 2010 to 2016
$2.1M
NIBIB NIH HHS R01 EB012547NINDS NIH HHS R01 NS060910
6 · The paper itself

Abstract

We describe and analyze a longitudinal diffusion tensor imaging (DTI) study relating changes in the microstructure of intracranial white matter tracts to cognitive disability in multiple sclerosis patients. In this application the scalar outcome and the functional exposure are measured longitudinally. This data structure is new and raises challenges that cannot be addressed with current methods and software. To analyze the data, we introduce a penalized functional regression model and inferential tools designed specifically for these emerging types of data. Our proposed model extends the Generalized Linear Mixed Model by adding functional predictors; this method is computationally feasible and is applicable when the functional predictors are measured densely, sparsely or with error. An online appendix compares two implementations, one likelihood-based and the other Bayesian, and provides the software used in simulations; the likelihood-based implementation is included as the lpfr() function in the R package refund available on CRAN.

Identifiers

PMID22679339
PMCPMC3366511

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.