ArticleCirculation. Cardiovascular imaging2012
Cardiac micro-computed tomography imaging of the aging coronary vasculature.
Article in Circulation. Cardiovascular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Temporal inhibition of ADAM17 in fibroblasts reduces stiffness and promotes vascularization following myocardial infarction.Cardiovascular research · 2026Article
- Immersion-Based Clearing and Autofluorescence Quenching in Myocardial Tissue.Microcirculation (New York, N.Y. : 1994) · 2025Article
- Pre-Clinical Models of Heart Failure with Preserved Ejection Fraction: Advancing Knowledge for Device Based Therapies.Annals of biomedical engineering · 2025Review
- Radiomics Signature of Aging Myocardium in Cardiac Photon-Counting Computed Tomography.Diagnostics (Basel, Switzerland) · 2025Article
- μCT imaging of a multi-organ vascular fingerprint in rats.PloS one · 2024Article
- Three-dimensional visualization of heart-wide myocardial architecture and vascular network simultaneously at single-cell resolution.Frontiers in cardiovascular medicine · 2022Article
- Microcomputed analysis of nerve angioarchitecture after combined stem cell delivery and surgical angiogenesis to nerve allograft.Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 2021Article
- Emerging methods for the characterization of ischemic heart disease: ultrafast Doppler angiography, micro-CT, photon-counting CT, novel MRI and PET techniques, and artificial intelligence.European radiology experimental · 2021Review
- A Review of Ex Vivo X-ray Microfocus Computed Tomography-Based Characterization of the Cardiovascular System.International journal of molecular sciences · 2021Review
- Micro-CT-Based Quantification of Extracted Thrombus Burden Characteristics and Association With Angiographic Outcomes in Patients With ST-Elevation Myocardial Infarction: The QUEST-STEMI Study.Frontiers in cardiovascular medicine · 2021Article
- A rapid, nondestructive method for vascular network visualization.BioTechniques · 2020Article
- Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis.Journal of the American Heart Association · 2017Article
- Correlative Imaging of the Murine Hind Limb Vasculature and Muscle Tissue by MicroCT and Light Microscopy.Scientific reports · 2017Article
- Cardiorenal fibrosis and dysfunction in aging: Imbalance in mediators and regulators of collagen.Peptides · 2016Article
- Bioengineering Human Myocardium on Native Extracellular Matrix.Circulation research · 2016Article
- Three-Dimensional Imaging of the Developing Vasculature within Stem Cell-Seeded Scaffolds Cultured in ovo.Frontiers in physiology · 2016Article
- Quantitative assessment of myocardial fibrosis in an age-related rat model by ex vivo late gadolinium enhancement magnetic resonance imaging with histopathological correlation.Computers in biology and medicine · 2015Article
- Micro-CT of rodents: state-of-the-art and future perspectives.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2014Review
- CD-NP: a novel engineered dual guanylyl cyclase activator with anti-fibrotic actions in the heart.PloS one · 2012Article
- Optimizing imaging of the rat pulmonary microvasculature by micro-computed tomography.Pulmonary circulationArticle
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Authors and funding
10 authors.
Funding
Abstract
backgroundAlterations at the level of the coronary circulation with aging may play an important role in the evolution of age-associated changes in left ventricular (LV) fibrosis and function. However these age-associated changes in the coronary vasculature remain poorly defined primarily due to the lack of high resolution imaging technologies. The current study was designed to utilize cardiac micro-computed tomography (micro-CT) technology as a novel imaging strategy, to define the 3-dimensional coronary circulation in the young and aged heart and its relationship to LV fibrosis and function. METHODS AND
resultsYoung (2 months old; n=10) and aged (20 months old; n=10) Fischer rats underwent cardiac micro-CT imaging as well as echocardiography, blood pressure, and fibrosis analysis. Importantly, when indexed to LV mass, which increased with age, the total and intramyocardial vessel volumes were lower, whereas the epicardial vessel volume, with and without indexing to LV mass, was significantly higher in the aged hearts compared with the young hearts. Moreover, the aged hearts had a significantly lower percentage of intramyocardial vessel volume and a significantly higher percentage of epicardial vessel volume, when normalized to the total vessel volume, compared with the young hearts. Further, the aged hearts had significant LV fibrosis and mild LV dysfunction compared with the young hearts.
conclusionsThis micro-CT imaging study reports the reduction in normalized intramyocardial vessel volume within the aged heart, in association with increased epicardial vessel volume, in the setting of increased LV fibrosis, and mild LV dysfunction.
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