ArticleJournal of applied physiology (Bethesda, Md. : 1985)2012
Exercise training and muscle microvascular oxygenation: functional role of nitric oxide.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- The Effect of Acute Beetroot Juice and Caffeine Supplementation on Specific Judo Performance During a Simulated Competition Day in Judo Athletes.European journal of sport science · 2026Trial
- Short-Term L-Citrulline Supplementation Does Not Affect Inspiratory Muscle Oxygenation and Respiratory Performance in Older Adults.Nutrients · 2023Trial
- The effect of dietary nitrate on exercise capacity in chronic kidney disease: a randomized controlled pilot study.Nitric oxide : biology and chemistry · 2021Trial
- Targeting lung heme iron by aerosol hemopexin adminstration in sickle cell disease pulmonary hypertension.Free radical biology & medicine · 2025Article
- Endurance training improves oxygen uptake/demand mismatch, metabolic flexibility and recovery in patients with sickle cell disease.Haematologica · 2024Article
- Microvascular Adaptations to Muscle Stretch: Findings From Animals and the Elderly.Frontiers in physiology · 2022Review
- Hemopexin dosing improves cardiopulmonary dysfunction in murine sickle cell disease.Free radical biology & medicine · 2021Article
- The role of vascular function on exercise capacity in health and disease.The Journal of physiology · 2021Review
- Effect of healthy aging and sex on middle cerebral artery blood velocity dynamics during moderate-intensity exercise.American journal of physiology. Heart and circulatory physiology · 2018Article
- Probing under pressure: a look inside the compartmental haemodynamics of skeletal muscle during rest and contraction.The Journal of physiology · 2018Article
- Neuronal nitric oxide synthase regulation of skeletal muscle functional hyperemia: exercise training and moderate compensated heart failure.Nitric oxide : biology and chemistry · 2018Article
- Skeletal muscle microvascular and interstitial PO2 from rest to contractions.The Journal of physiology · 2018Article
- Exercise limitations in heart failure with reduced and preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Endurance, interval sprint, and resistance exercise training: impact on microvascular dysfunction in type 2 diabetes.American journal of physiology. Heart and circulatory physiology · 2016Review
- Physical activity-induced remodeling of vasculature in skeletal muscle: role in treatment of type 2 diabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
- Exercise training in chronic heart failure: improving skeletal muscle O2 transport and utilization.American journal of physiology. Heart and circulatory physiology · 2015Review
- Effects of nitrite infusion on skeletal muscle vascular control during exercise in rats with chronic heart failure.American journal of physiology. Heart and circulatory physiology · 2015Article
- Microvascular oxygen pressures in muscles comprised of different fiber types: Impact of dietary nitrate supplementation.Nitric oxide : biology and chemistry · 2015Article
- Heterogeneity of Muscle Blood Flow and Metabolism: Influence of Exercise, Aging, and Disease States.Exercise and sport sciences reviews · 2015Review
- Endurance training facilitates myoglobin desaturation during muscle contraction in rat skeletal muscle.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Exercise training induces multiple adaptations within skeletal muscle that may improve local O(2) delivery-utilization matching (i.e., Po(2)mv). We tested the hypothesis that increased nitric oxide (NO) function is intrinsic to improved muscle Po(2)mv kinetics from rest to contractions after exercise training. Healthy young Sprague-Dawley rats were assigned to sedentary (n = 18) or progressive treadmill exercise training (n = 10; 5 days/wk, 6-8 wk, final workload of 60 min/day at 35 m/min, -14% grade) groups. Po(2)mv was measured via phosphorescence quenching in the spinotrapezius muscle at rest and during 1-Hz twitch contractions under control (Krebs-Henseleit solution), sodium nitroprusside (SNP, NO donor; 300 μM), and N(G)-nitro-L-arginine methyl ester (l-NAME, nonspecific NO synthase blockade; 1.5 mM) superfusion conditions. Exercise-trained rats had greater peak oxygen uptake (Vo(2 peak)) than their sedentary counterparts (81 ± 1 vs. 72 ± 2 ml · kg(-1) · min(-1), respectively; P < 0.05). Exercise-trained rats had significantly slower Po(2)mv fall throughout contractions (τ(1); time constant for the first component) during control (sedentary: 8.1 ± 0.6; trained: 15.2 ± 2.8 s). Compared with control, SNP slowed τ(1) to a greater extent in sedentary rats (sedentary: 38.7 ± 5.6; trained: 26.8 ± 4.1 s; P > 0.05) whereas l-NAME abolished the differences in τ(1) between sedentary and trained rats (sedentary: 12.0 ± 1.7; trained: 11.2 ± 1.4 s; P < 0.05). Our results indicate that endurance exercise training leads to greater muscle microvascular oxygenation across the metabolic transient following the onset of contractions (i.e., slower Po(2)mv kinetics) partly via increased NO-mediated function, which likely constitutes an important mechanism for training-induced metabolic adaptations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.