ReviewJournal of applied physiology (Bethesda, Md. : 1985)2012
Mechanisms of sympathetic regulation in orthostatic intolerance.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03970551 (Lower Body Muscle Pre-activation in Initial Orthostatic Hypotension), which is not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lower Body Muscle Pre-activation in Initial Orthostatic Hypotension: Effects on Orthostatic Tolerance
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- Hemodynamic orthostatic dizziness/vertigo: Diagnostic criteria.Journal of vestibular research : equilibrium & orientationGuideline
- On-feet isometric bracing maintains cerebral arterial blood velocity during lower body negative pressure via preload augmentation.Experimental physiology · 2026Trial
- An Intervention of Four Weeks of Time-Restricted Eating (16/8) in Male Long-Distance Runners Does Not Affect Cardiometabolic Risk Factors.Nutrients · 2023Trial
- A double-blind placebo-controlled cross-over study of the vascular effects of midodrine in neuropathic compared with hyperadrenergic postural tachycardia syndrome.Clinical science (London, England : 1979) · 2014Trial
- Autonomic Dysfunction in Patients withPathogens (Basel, Switzerland) · 2026Article
- The physiologic power of fluid circulation and implications for fluid therapy.Frontiers in veterinary science · 2026Review
- GDF15 regulates development and growth of sympathetic neurons to enhance energy expenditure and thermogenesis.Experimental & molecular medicine · 2025Article
- Linking Neurocardiovascular Responses in the Active Stand Test to Adverse Outcomes: Insights from the Irish Longitudinal Study on Ageing (TILDA).Sensors (Basel, Switzerland) · 2025Article
- Attenuated cardiac autonomic function in patients with long-COVID with impaired orthostatic hemodynamics.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Haemodynamic Patterns in Reflex Syncope: Insights from Head-Up Tilt Tests in Adults and Children.Journal of clinical medicine · 2025Article
- Hemodynamic responses at anaerobic threshold during exercise in preload insufficiency.European journal of clinical investigation · 2025Article
- Assessment of symptoms in myalgic encephalomyelitis/chronic fatigue syndrome: a comparative study of existing scales.Frontiers in neurology · 2025Review
- Hyperventilation during rest and exercise in orthostatic intolerance and Spiky-Leaky Syndrome.Frontiers in neurology · 2025Article
- Cerebral homeostasis and orthostatic responses in residents of the highest city in the world.Scientific reports · 2024Article
- Were Frailty Identification Criteria Created Equal? A Comparative Case Study on Continuous Non-Invasively Collected Neurocardiovascular Signals during an Active Standing Test in the Irish Longitudinal Study on Ageing (TILDA).Sensors (Basel, Switzerland) · 2024Observational
- Insult of Ultraendurance Events on Blood Pressure: A Systematic Review and Meta-Analysis.Cureus · 2023Review
- Association between Daytime Sleepiness, Fatigue and Autonomic Responses during Head-Up Tilt Test in Multiple Sclerosis Patients.Brain sciences · 2023Article
- Article
- A Novel Methodology for the Synchronous Collection and Multimodal Visualization of Continuous Neurocardiovascular and Neuromuscular Physiological Data in Adults with Long COVID.Sensors (Basel, Switzerland) · 2022Article
- Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1.Autonomic neuroscience : basic & clinical · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Sympathetic circulatory control is key to the rapid cardiovascular adjustments that occur within seconds of standing upright (orthostasis) and which are required for bipedal stance. Indeed, patients with ineffective sympathetic adrenergic vasoconstriction rapidly develop orthostatic hypotension, prohibiting effective upright activities. One speaks of orthostatic intolerance (OI) when signs, such as hypotension, and symptoms, such as lightheadedness, occur when upright and are relieved by recumbence. The experience of transient mild OI is part of daily life. However, many people experience episodic acute OI as postural faint or chronic OI in the form of orthostatic tachycardia and orthostatic hypotension that significantly reduce the quality of life. Potential mechanisms for OI are discussed including forms of sympathetic hypofunction, forms of sympathetic hyperfunction, and OI that results from regional blood volume redistribution attributable to regional adrenergic hypofunction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.