Evidence map›Paper›PMID 22678767›Full record

ReviewHeart failure reviews2013

Mechanisms underlying the autonomic modulation of ventricular fibrillation initiation--tentative prophylactic properties of vagus nerve stimulation on malignant arrhythmias in heart failure.

Kieran E Brack, James Winter, G André Ng

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Heart failure reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.

  1. Pooled it
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  6. Review
  7. Vasopressin and cardiovascular autonomic adjustment in chronic hypertensive pregnancy.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Article
  8. Exploring the prospects, advancements, and challenges ofFrontiers in cellular neuroscience · 2024
    Article
  9. Article
  10. Article
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  12. Review
  13. Article
  14. Autonomic modulation of ventricular electrical activity: recent developments and clinical implications.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Review
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kieran E BrackCardiology Group, Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK.
James Winter
G André Ng
University of Leicester · GBNIHR Leicester Cardiovascular Biomedical Research Unit · GB

Funding

British Heart Foundation FS/12/2/23900British Heart Foundation PG/09/039
6 · The paper itself

Abstract

Classical physiology teaches that vagal post-ganglionic nerves modulate the heart via acetylcholine acting at muscarinic receptors, whilst it is accepted that vagus nerve stimulation (VNS) slows heart rate, atrioventricular conduction and decreases atrial contraction; there is continued controversy as to whether the vagus has any significant direct effect on ventricular performance. Despite this, there is a significant body of evidence from experimental and clinical studies, demonstrating that the vagus nerve has an anti-arrhythmic action, protecting against induced and spontaneously occurring ventricular arrhythmias. Over 100 years ago Einbrodt first demonstrated that direct cervical VNS significantly increased the threshold for experimentally induced ventricular fibrillation. A large body of evidence has subsequently been collected supporting the existence of an anti-arrhythmic effect of the vagus on the ventricle. The development of prognostic indicators of heart rate variability and baroreceptor reflex sensitivity--measures of parasympathetic tone and reflex activation respectively--and the more recent interest in chronic VNS therapy are a direct consequence of the earlier experimental studies. Despite this, mechanisms underlying the anti-arrhythmic actions of the vagus nerve have not been fully characterised and are not well understood. This review summarises historical and recently published data to highlight the importance of this powerful endogenous protective phenomenon.

Indexed as

Vagus Nerve StimulationAcetylcholineAnimalsEndothelium-Dependent Relaxing FactorsEvidence-Based MedicineHeart Conduction SystemHeart FailureHumansNitric OxidePrognosisReceptors, MuscarinicVagus NerveVasodilator AgentsVentricular FibrillationAcetylcholineEndothelium-Dependent Relaxing FactorsNitric OxideReceptors, MuscarinicVasodilator Agents

Identifiers

PMID22678767
PMCPMC3677978
OpenAlexW2148936486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.