ArticleMycopathologia2012
HOG-MAPK signaling regulates the adaptive responses of Aspergillus fumigatus to thermal stress and other related stress.
Article in Mycopathologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Genome-wide characterization of histidine kinase genes in Aciculosporium take and their potential roles in cytokinin sensing.Journal of applied genetics · 2026Article
- Hybrid histidine kinases shape the architecture of the high osmolarity glycerol (HOG) pathway: from Saccharomyces cerevisiae to the priority pathogen Aspergillus fumigatus and other filamentous fungi.FEMS microbiology reviews · 2026Review
- Structure and distribution of sensor histidine kinases in the fungal kingdom.Current genetics · 2024Article
- AfuPmV-1-InfectedJournal of fungi (Basel, Switzerland) · 2023Article
- Host- and virus-induced gene silencing of HOG1-MAPK cascade genes in Rhizophagus irregularis inhibit arbuscule development and reduce resistance of plants to drought stress.Plant biotechnology journal · 2023Article
- Article
- Novel Antifungal Agents and Their Activity againstJournal of fungi (Basel, Switzerland) · 2020Review
- Stress-Activated Protein Kinases in Human Fungal Pathogens.Frontiers in cellular and infection microbiology · 2019Review
- Genome-wide identification and expression profile analysis of the HOG gene family in Aspergillus oryzae.World journal of microbiology & biotechnology · 2018Article
- Global gene expression reveals stress-responsive genes in Aspergillus fumigatus mycelia.BMC genomics · 2017Article
- Role ofFrontiers in microbiology · 2017Article
- Role ofBiotechnology for biofuels · 2017Article
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- Identification of the role of a MAP kinase Tmk2 in Hypocrea jecorina (Trichoderma reesei).Scientific reports · 2014Article
- In vitro analyses of mild heat stress in combination with antifungal agents against Aspergillus fumigatus biofilm.Antimicrobial agents and chemotherapy · 2014Article
- Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspergillus fumigatus is naturally exposed to a highly variable environment and subjected to various kinds of stresses. High-osmolarity glycerol mitogen-activated protein kinase (HOG-MAPK) pathway plays a crucial role in regulating cellular homeostasis in response to environmental changes. Here, we explored the contribution of HOG-MAPK pathway to the adaptive responses to thermal stress and other related stresses in A. fumigatus. We observed the phenotype features of wild-type strains and their derived mutants at 37 and 48 °C, and the results suggested that tcsB participates in response to high temperature. Furthermore, susceptibility test for antifungal drugs showed that SHO1 branch is probably involved in the susceptibility of A. fumigatus to itraconazole at high temperature. Although sakA expression at mRNA level appeared unchanged in wild-type AF293 subjected to thermal stress, phosphorylated SakAp level increased significantly in the strains exposed to cold stress, 250 mmol/L nystatin or 10 % dimethyl sulfoxide in a manner dependent on the SLN1 branch and independent on the SHO1 branch. Taken together, these results indicate that HOG-MAPK pathway, especially the SLN1 branch, plays an important role in the adaptations of A. fumigatus to thermal stress and other related stresses.
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