ArticleMolecules (Basel, Switzerland)2012
Synthesis and in vitro cytotoxic evaluation of aminoquinones structurally related to marine isoquinolinequinones.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Targeting Cancer Cell Proliferation Using Piperazine-Linked Quinolinequinones: Mechanism and Metabolic Profile.Chemical biology & drug design · 2025Article
- Discovery of Potent IsoquinolinequinoneJournal of medicinal chemistry · 2024Article
- Novel Disperse Dyes Based on Enaminones: Synthesis, Dyeing Performance on Polyester Fabrics, and Potential Biological Activities.Molecules (Basel, Switzerland) · 2024Article
- New 2-Acetyl-3-aminophenyl-1,4-naphthoquinones: Synthesis andOxidative medicine and cellular longevity · 2020Article
- Green Synthesis and Electrochemical Properties of Mono- and Dimers Derived from Phenylaminoisoquinolinequinones.Molecules (Basel, Switzerland) · 2019Article
- Preparation of Novel Homodimers Derived from Cytotoxic Isoquinolinequinones. A Twin Drug Approach.Molecules (Basel, Switzerland) · 2018Article
- Access to New Cytotoxic Quinone-Amino Acid Conjugates Linked through A Vinylic Spacer from 2-Acylnaphthoquinones and Methyl 3-Aminocrotonate.Molecules (Basel, Switzerland) · 2017Article
- Flavoenzyme-mediated reduction reactions and antitumor activity of nitrogen-containing tetracyclic ortho-quinone compounds and their nitrated derivatives.EXCLI journal · 2017Article
- Synthesis and Cytotoxic Activity on Human Cancer Cells of Novel Isoquinolinequinone-Amino Acid Derivatives.Molecules (Basel, Switzerland) · 2016Article
- A Survey of Marine Natural Compounds and Their Derivatives with Anti-cancer Activity Reported in 2012.Molecules (Basel, Switzerland) · 2015Review
- Synthesis, half-wave potentials and antiproliferative activity of 1-aryl-substituted aminoisoquinolinequinones.Molecules (Basel, Switzerland) · 2014Article
- Eco-friendly synthesis and antiproliferative evaluation of some oxygen substituted diaryl ketones.Molecules (Basel, Switzerland) · 2013Article
- Synthesis and in vitro antiproliferative activity of new phenylaminoisoquinolinequinones against cancer cell lines.Molecules (Basel, Switzerland) · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The synthesis of 4-methoxycarbonyl-3-methylisoquinolinequinone (1) and a variety of its substitution products with amino-, alkylamino and halogen groups on the quinone nucleus is reported. The series of 6-, 7- and 6,7-subtituted isoquinolinequinones were evaluated in vitro for their cytotoxic activity using the MTT colorimetric method. All the newly synthesized compounds showed moderate to high potency against MRC-5 healthy lung fibroblasts and four human tumor cell lines: AGS gastric adenocarcinoma, SK-MES-1 lung, J82 bladder carcinoma, and HL-60 leukemia cells. Among the series, compounds 4b, 12 and 13 exhibited interesting antitumor activity against human gastric adenocarcinoma, human lung and human bladder carcinoma cancer cells. 7-Amino-6-bromoisoquinoline-5,8-quinone (13) was found to be the most promising active compound against the tested cancer cell lines, with IC₅₀ values in the 0.21-0.49 μM range, lower than the anti-cancer agent etoposide used as reference.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.