ArticleNature2012
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel.
Article in Nature, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 269 papers.
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Who cites it
269 citing papers in PubMed, 477 citations in OpenAlex.
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- The crucial decade that ion channels were proven to exist : The vision of Bertil Hille and Clay Armstrong and how it came through.Pflugers Archiv : European journal of physiology · 2025Review
- Redox-active electrolyte-based printed ionologic devices.Nature communications · 2025Article
- Voltage sensors.Molecular pharmacology · 2025Review
- Differential Inhibition by Cenobamate of Canonical Human Nav1.5 Ion Channels and Several Point Mutants.International journal of molecular sciences · 2025Article
- A structural atlas of druggable sites on NaChannels (Austin, Tex.) · 2024Review
- Structural biology and molecular pharmacology of voltage-gated ion channels.Nature reviews. Molecular cell biology · 2024Review
- The chemistry of electrical signaling in sodium channels from bacteria and beyond.Cell chemical biology · 2024Review
- Conotoxins Targeting Voltage-Gated Sodium Ion Channels.Pharmacological reviews · 2024Review
- Structural mechanism of voltage-gated sodium channel slow inactivation.Nature communications · 2024Article
- Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin.Nature communications · 2024Article
- Cholesterol modulates the structural dynamics of the paddle motif loop of KvAP voltage sensor.Current research in structural biology · 2024Article
- Voltage sensors of a NaNature communications · 2023Article
- Fifty years of gating currents and channel gating.The Journal of general physiology · 2023Review
- Ion channel selectivity through ion-modulated changes of selectivity filter pProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cannabidiol inhibits NaNature communications · 2023Article
- Structural mapping of NaNature communications · 2023Article
- Molecular Dynamics Simulations of Ion Permeation in Human Voltage-Gated Sodium Channels.Journal of chemical theory and computation · 2023Article
- Sensory input-dependent gain modulation of the optokinetic nystagmus by mid-infrared stimulation in pigeons.eLife · 2023Article
209 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
Abstract
Voltage-gated sodium (Na(v)) channels are essential for the rapid depolarization of nerve and muscle, and are important drug targets. Determination of the structures of Na(v) channels will shed light on ion channel mechanisms and facilitate potential clinical applications. A family of bacterial Na(v) channels, exemplified by the Na(+)-selective channel of bacteria (NaChBac), provides a useful model system for structure-function analysis. Here we report the crystal structure of Na(v)Rh, a NaChBac orthologue from the marine alphaproteobacterium HIMB114 (Rickettsiales sp. HIMB114; denoted Rh), at 3.05 Å resolution. The channel comprises an asymmetric tetramer. The carbonyl oxygen atoms of Thr 178 and Leu 179 constitute an inner site within the selectivity filter where a hydrated Ca(2+) resides in the crystal structure. The outer mouth of the Na(+) selectivity filter, defined by Ser 181 and Glu 183, is closed, as is the activation gate at the intracellular side of the pore. The voltage sensors adopt a depolarized conformation in which all the gating charges are exposed to the extracellular environment. We propose that Na(v)Rh is in an 'inactivated' conformation. Comparison of Na(v)Rh with Na(v)Ab reveals considerable conformational rearrangements that may underlie the electromechanical coupling mechanism of voltage-gated channels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.