ArticleNeurogenetics2012
A genome-wide analysis of 'Bounty' descendants implicates several novel variants in migraine susceptibility.
Article in Neurogenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- A multi-ancestry meta genome-wide association study of migraine among veterans: associations with traumatic brain injury, depression, and post-traumatic stress disorder.Molecular psychiatry · 2026Pooled it
- Role of CGRP pathway polymorphisms in migraine: a systematic review and impact on CGRP mAbs migraine therapy.The journal of headache and pain · 2021Pooled it
- AnGenes · 2026Article
- Review
- The interictal transcriptomic map of migraine without aura.The journal of headache and pain · 2025Article
- GRM7 deficiency, from excitotoxicity and neuroinflammation to neurodegeneration: Systematic review of GRM7 deficient patients.Brain, behavior, & immunity - health · 2024Review
- Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors.Communications biology · 2024Article
- Sex Differences in Migraine: A Twin Study.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Advances in genetics of migraine.The journal of headache and pain · 2019Review
- Explaining Pathogenicity of Congenital Zika and Guillain-Barré Syndromes: Does Dysregulation of RNA Editing Play a Role?BioEssays : news and reviews in molecular, cellular and developmental biology · 2019Article
- Implications for the migraine SNP rs1835740 in a Swedish cluster headache population.The journal of headache and pain · 2018Article
- Molecular genetic overlap between migraine and major depressive disorder.European journal of human genetics : EJHG · 2018Article
- The NRP1 migraine risk variant shows evidence of association with menstrual migraine.The journal of headache and pain · 2018Article
- Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems.Alcoholism, clinical and experimental research · 2017Review
- Gene-centric analysis implicates nuclear encoded mitochondrial protein gene variants in migraine susceptibility.Molecular genetics & genomic medicine · 2017Article
- Common polygenic variation contributes to risk of migraine in the Norfolk Island population.Human genetics · 2015Article
- Migraine genetics: current findings and future lines of research.Neurogenetics · 2015Article
- Case-control study of ADARB1 and ADARB2 gene variants in migraine.The journal of headache and pain · 2015Article
- Genome-wide association studies in neurology.Annals of translational medicine · 2014Review
- Migraine and estrogen.Current opinion in neurology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
Migraine is a common neurological disease with a complex genetic aetiology. The disease affects ~12% of the Caucasian population and females are three times more likely than males to be diagnosed. In an effort to identify loci involved in migraine susceptibility, we performed a pedigree-based genome-wide association study of the isolated population of Norfolk Island, which has a high prevalence of migraine. This unique population originates from a small number of British and Polynesian founders who are descendents of the Bounty mutiny and forms a very large multigenerational pedigree (Bellis et al.; Human Genetics, 124(5):543-5542, 2008). These population genetic features may facilitate disease gene mapping strategies (Peltonen et al.; Nat Rev Genet, 1(3):182-90, 2000. In this study, we identified a high heritability of migraine in the Norfolk Island population (h (2) = 0.53, P = 0.016). We performed a pedigree-based GWAS and utilised a statistical and pathological prioritisation approach to implicate a number of variants in migraine. An SNP located in the zinc finger protein 555 (ZNF555) gene (rs4807347) showed evidence of statistical association in our Norfolk Island pedigree (P = 9.6 × 10(-6)) as well as replication in a large independent and unrelated cohort with >500 migraineurs. In addition, we utilised a biological prioritisation to implicate four SNPs, in within the ADARB2 gene, two SNPs within the GRM7 gene and a single SNP in close proximity to a HTR7 gene. Association of SNPs within these neurotransmitter-related genes suggests a disrupted serotoninergic system that is perhaps specific to the Norfolk Island pedigree, but that might provide clues to understanding migraine more generally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.