ArticleCancer prevention research (Philadelphia, Pa.)2012
Dietary methyl donor depletion protects against intestinal tumorigenesis in Apc(Min/+) mice.
Article in Cancer prevention research (Philadelphia, Pa.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Dose-Response Relationship of Niclosamide and Metformin Combination in ApcGut and liver · 2026Article
- The Double-Edged Nature of Methyl Donors in Cancer Development from Prevention to Progression.International journal of molecular sciences · 2025Review
- Association of dietary intake of folate, serum folate, and red blood cell folate with mortality risk in patients with depression: a population-based longitudinal cohort study.Journal of health, population, and nutrition · 2025Article
- The role of diet in cancer: the potential of shaping public policy and clinical outcomes in the UK.Genes & nutrition · 2024Review
- Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate: A Narrative Review.Nutrients · 2023Review
- Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.Nature metabolism · 2023Article
- The Timing and Duration of Folate Restriction Differentially Impacts Colon Carcinogenesis.Nutrients · 2021Article
- Fatty acid metabolism and colon cancer protection by dietary methyl donor restriction.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Phospholipase D and Choline Metabolism.Handbook of experimental pharmacology · 2020Review
- Methyl Donor Deficiency Blocks Colorectal Cancer Development by Affecting Key Metabolic Pathways.Cancer prevention research (Philadelphia, Pa.) · 2020Article
- Review
- Methyl-donor depletion of head and neck cancer cells in vitro establishes a less aggressive tumour cell phenotype.European journal of nutrition · 2018Article
- Metabolic control of epigenetics in cancer.Nature reviews. Cancer · 2016Review
- Dietary Methyl Donor Depletion Suppresses Intestinal Adenoma Development.Cancer prevention research (Philadelphia, Pa.) · 2016Article
- Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice.BMC cancer · 2016Article
- One-Carbon Metabolism and Colorectal Cancer: Potential Mechanisms of Chemoprevention.Current pharmacology reports · 2015Article
- Suppression of colon carcinogenesis by targeting Notch signaling.Carcinogenesis · 2013Article
- Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2013Review
- The Combination of Methionine Adenosyltransferase 2A (MAT2A) Inhibitor AG-270 and Recombinant Methioninase Is Not Cancer-selective in a Co-culture Model of Colon Cancer Cells and Normal Fibroblasts.Cancer diagnosis & prognosisArticle
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Despite recent population data, the influence of dietary folate supplementation on colon cancer risk remains controversial. This study examines the effects of folate deficiency, in combination with choline, methionine, and vitamin B12 depletion, on intestinal tumorigenesis in Apc(Min/+) mice. Methyl donor sufficient (MDS) and deficient (MDD) diets were started at five or 10 weeks of age and tumors evaluated at 16 weeks. MDD suppressed intestinal tumor formation in Apc(Min/+) mice (~80%) when started at five weeks of age. The protective effect was lost when MDD was initiated at 10 weeks of age, indicating an important time dependency on cancer suppression. Concomitant with cancer protection, MDD restricted body weight gain. Therefore, a second study was conducted in which MDS was given ad libitum or pair-fed with MDD. Although small intestinal tumors were reduced 54% in pair-fed MDS mice, MDD caused a further reduction (96%). In colon, although MDD did not affect tumor numbers, tumor size was reduced. Gene expression profiling of normal-appearing colonic mucosa after 11 weeks on MDD identified a total of 493 significantly downregulated genes relative to the MDS group. Pathway analysis placed many of these genes within general categories of inflammatory signaling and cell-cycle regulation, consistent with recently published human data obtained during folate depletion. Further studies are warranted to investigate the complex interplay of methyl donor status and cancer protection in high-risk populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.