ArticleMechanisms of development2012
Ligand-independent activation of the Hedgehog pathway displays non-cell autonomous proliferation during eye development in Drosophila.
Article in Mechanisms of development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Identification of sex chromosome, sex-biased gene expression and dosage compensation in the pygmy mole cricket Xya riparia (Orthoptera: Tridactyloidea).BMC genomics · 2026Article
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- The histone demethylase Kdm5 controls Hid-induced cell death inFrontiers in cell death · 2024Article
- Article
- Membrane potential regulates Hedgehog signalling in the Drosophila wing imaginal disc.EMBO reports · 2021Article
- Article
- Modelling Cooperative Tumorigenesis inBioMed research international · 2018Review
- Hedgehog signalling is required for cell survival in Drosophila wing pouch cells.Scientific reports · 2017Article
- Clonal cooperativity in heterogenous cancers.Seminars in cell & developmental biology · 2017Review
- Targeted resequencing identifies PTCH1 as a major contributor to ocular developmental anomalies and extends the SOX2 regulatory network.Genome research · 2016Article
- Pathway modulations and epigenetic alterations in ovarian tumorbiogenesis.Journal of cellular physiology · 2014Review
- Mechanisms of cell competition: themes and variations.The Journal of cell biology · 2013Review
- Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila.Cell death and differentiation · 2013Article
- Dampening the signals transduced through hedgehog via microRNA miR-7 facilitates notch-induced tumourigenesis.PLoS biology · 2013Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Deregulation of the Hedgehog (Hh) signaling pathway is associated with the development of human cancer including medullobastoma and basal cell carcinoma. Loss of Patched or activation of Smoothened in mouse models increases the occurrence of tumors. Likewise, in a Drosophila eye model, deregulated Hedgehog signaling causes overgrowth of eye and head tissues. Surprisingly, we show that cells with deregulated Hh signaling do not or only little contribute to the tissue overgrowth. Instead, they become more sensitive to apoptosis and may eventually be eliminated. Nevertheless, these mutant cells increase proliferation in the adjacent wild-type tissue, i.e., in a non-cell autonomous manner. This non-cell autonomous effect is position-dependent and restricted to mutant cells in the anterior portion of the eye. We also observe precocious non-cell autonomous differentiation in genetic mosaics with deregulated Hh signaling. Together, these non-cell autonomous growth and differentiation phenotypes in the Drosophila eye model reveal another strategy by which oncogenes may generate a supportive micro-environment for tumor growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.