Trial reportJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2012
The ventricular volume variability study of the Pediatric Heart Network: study design and impact of beat averaging and variable type on the reproducibility of echocardiographic measurements in children with chronic dilated cardiomyopathy.
Trial report in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Recommendations for cardiomyopathy surveillance for survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group.The Lancet. Oncology · 2015Guideline
- Comparison of echocardiographic measurements to invasive measurements of diastolic function in infants with single ventricle physiology: a report from the Pediatric Heart Network Infant Single Ventricle Trial.Cardiology in the young · 2019Trial
- Influence of Aortic Stiffness on Aortic-Root Growth Rate and Outcome in Patients With the Marfan Syndrome.The American journal of cardiology · 2018Trial
- Rationale and design of the Children's Oncology Group (COG) study ALTE1621: a randomized, placebo-controlled trial to determine if low-dose carvedilol can prevent anthracycline-related left ventricular remodeling in childhood cancer survivors at high risk for developing heart failure.BMC cardiovascular disorders · 2016Trial
- Changes in speckle tracking echocardiography measures of ventricular function after percutaneous implantation of the Edwards SAPIEN transcatheter heart valve in the pulmonary position.Echocardiography (Mount Kisco, N.Y.) · 2015Trial
- Variability of M-mode versus two-dimensional echocardiography measurements in children with dilated cardiomyopathy.Pediatric cardiology · 2014Trial
- Predictors of disease progression in pediatric dilated cardiomyopathy.Circulation. Heart failure · 2013Trial
- Japan at the limits of viability: national experience and evolving outcomes of infants born at 22-23 weeks' gestation.Pediatric research · 2026Review
- Pulmonary Peak Flow Assessment: An Easy Tool for Cardiac Output Estimation in Hemodynamically Stable Neonates.International journal of pediatrics · 2026Article
- Accuracy and Reproducibility of a Modified Echocardiographic Method for Right Ventricular Output Calculation in Neonates.Journal of cardiovascular development and disease · 2025Article
- Semi-supervised segmentation of cardiac chambers from LGE-CMR using feature consistency awareness.BMC cardiovascular disorders · 2024Article
- Global longitudinal strain is an informative index of left ventricular performance in neonates receiving intensive care.Scientific reports · 2024Article
- Deep learning assisted measurement of echocardiographic left heart parameters: improvement in interobserver variability and workflow efficiency.The international journal of cardiovascular imaging · 2023Article
- Impact of Sex and Obesity on Echocardiographic Parameters in Children and Adolescents.Pediatric cardiology · 2022Article
- Feasibility, Reproducibility and Reference Ranges of Left Atrial Strain in Preterm and Term Neonates in the First 48 h of Life.Diagnostics (Basel, Switzerland) · 2022Article
- Brazilian Position Statement on the Use Of Multimodality Imaging in Cardio-Oncology - 2021.Arquivos brasileiros de cardiologia · 2021Article
- Height Versus Body Surface Area to Normalize Cardiovascular Measurements in Children Using the Pediatric Heart Network Echocardiographic Z-Score Database.Pediatric cardiology · 2021Article
- Use of Machine Learning to Improve Echocardiographic Image Interpretation Workflow: A Disruptive Paradigm Change?Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2021Article
- Speckle tracking echocardiographically-based analysis of ventricular strain in children: an intervendor comparison.Cardiovascular ultrasound · 2020Article
- Challenges With Left Ventricular Functional Parameters: The Pediatric Heart Network Normal Echocardiogram Database.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2019Article
Corrections and comments
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Authors and funding
18 authors at 10 institutions in 2 countries.
Funding
Abstract
backgroundClinical trials often rely on echocardiographic measures of left ventricular size and function as surrogate end points. However, the quantitative impact of factors that affect the reproducibility of these measures is unknown. To address this issue, the National Heart, Lung, and Blood Institute-funded Pediatric Heart Network designed a longitudinal observational study of children with known or suspected dilated cardiomyopathy aged 0 to 22 years from eight pediatric clinical centers.
methodsClinical data were collected together with 150 echocardiographic indices of left ventricular size and function. Separate observers performed duplicate echocardiographic imaging. Multiple observers performed measurements from three cardiac cycles to enable assessment of intraobserver and interobserver variability. The impacts of beat averaging (BA), observer type (local vs core), and variable type (areas, calculations, dimensions, slopes, time intervals, and velocities) on measurement reproducibility were studied. The outcome measure was percentage error (100 × difference/mean).
resultsOf 173 enrolled subjects, 131 met criteria for dilated cardiomyopathy. BA, variable type and observer type all influenced percentage error (P < .0001). Core interobserver percentage error (medians, 11.4%, 10.2%, and 9.3% for BA using one, two, and three beats, respectively) was approximately twice the intraobserver percentage error (medians, 6.3%, 4.9%, and 4.2% for BA using one, two, and three beats, respectively). Slopes and calculated variables exhibited high percentage error despite BA. Chamber dimensions, areas, velocities, and time intervals exhibited low percentage error.
conclusionsThis comprehensive evaluation of quantitative echocardiographic methods will provide a valuable resource for the design of future pediatric studies. BA and a single core lab observer improve the reproducibility of echocardiographic measurements in children with dilated cardiomyopathy. Certain measurements are highly reproducible, while others, despite BA, are poorly reproducible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.