ArticleJournal of the American College of Cardiology2012
Autonomic and hemodynamic origins of pre-hypertension: central role of heredity.
Article in Journal of the American College of Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.Clinical physiology and functional imaging · 2025Trial
- Randomised, double-blind, placebo-controlled, assessment of the efficacy and safety of dietary supplements in prehypertension.Journal of human hypertension · 2017Trial
- Nebivolol monotherapy in younger adults (younger than 55 years) with hypertension: a randomized, placebo-controlled trial.Journal of clinical hypertension (Greenwich, Conn.) · 2013Trial
- Central hemodynamics in prehypertension: effect of the β-adrenergic antagonist nebivolol.Journal of clinical hypertension (Greenwich, Conn.) · 2013Trial
- Sympathoexcitation and impaired arterial baroreflex sensitivity are linked to vascular inflammation in individuals with elevated resting blood pressure.Physiological reports · 2019Article
- A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function.Scientific reports · 2019Article
- Elevated resting blood pressure augments autonomic imbalance in posttraumatic stress disorder.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Autonomic and Vascular Control in Prehypertensive Subjects with a Family History of Arterial Hypertension.Arquivos brasileiros de cardiologia · 2018Article
- Prehypertension is a comorbid state with autonomic and metabolic dysfunction.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Polyphenols: a Promising Nutritional Approach to Prevent or Reduce the Progression of Prehypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2016Review
- Prehypertension: Defining the Transitional Phenotype.Current hypertension reports · 2016Review
- Effects of Anxiety and Depression on Arterial Elasticity of Subjects With Suboptimal Physical Health.Clinical cardiology · 2015Observational
- Resistive and pulsatile arterial hemodynamics and cardiovascular events: the Multiethnic Study of Atherosclerosis.Journal of the American Heart Association · 2014Observational
- Physiology: hemodynamics, endothelial function, renin-angiotensin-aldosterone system, sympathetic nervous system.Journal of the American Society of Hypertension : JASH · 2014Review
- A validation of estimated total peripheral resistance using twin data.Biomedical sciences instrumentation · 2014Article
- Genetic variation at the delta-sarcoglycan (SGCD) locus elevates heritable sympathetic nerve activity in human twin pairs.Journal of neurochemistry · 2013Article
- Molecular sources of residual cardiovascular risk, clinical signals, and innovative solutions: relationship with subclinical disease, undertreatment, and poor adherence: implications of new evidence upon optimizing cardiovascular patient outcomes.Vascular health and risk management · 2013Review
Corrections and comments
- Commented on by
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThe purpose of this study is to better understand the origins and progression of pre-hypertension.
backgroundPre-hypertension is a risk factor for progression to hypertension, cardiovascular disease, and increased mortality. We used a cross-sectional twin study design to examine the role of heredity in likely pathophysiological events (autonomic or hemodynamic) in pre-hypertension.
methodsEight hundred twelve individuals (337 normotensive, 340 pre-hypertensive, 135 hypertensive) were evaluated in a sample of twin pairs, their siblings, and other family members. They underwent noninvasive hemodynamic, autonomic, and biochemical testing, as well as estimates of trait heritability (the percentage of trait variance accounted for by heredity) and pleiotropy (the genetic covariance or shared genetic determination of traits) by variance components.
resultsIn the hemodynamic realm, an elevation of cardiac contractility prompted increased stroke volume, in turn increasing cardiac output, which elevated blood pressure into the pre-hypertension range. Autonomic monitoring detected an elevation of norepinephrine secretion plus a decline in cardiac parasympathetic tone. Twin pair variance components documented substantial heritability as well as joint genetic determination for blood pressure and the contributory autonomic and hemodynamic traits. Genetic variation at a pathway locus also indicated pleiotropic effects on contractility and blood pressure.
conclusionsElevated blood pressure in pre-hypertension results from increased cardiac output, driven by contractility as well as heart rate, which may reflect both diminished parasympathetic and increased sympathetic tone. In the face of increased cardiac output, systemic vascular resistance fails to decline homeostatically. Such traits display substantial heritability and shared genetic determination, although by loci not yet elucidated. These findings clarify the role of heredity in the origin of pre-hypertension and its autonomic and hemodynamic pathogenesis. The results also establish pathways that suggest new therapeutic targets for pre-hypertension, or approaches to its prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.