Evidence map›Paper›PMID 22676934›Full record

ReviewJournal of the American College of Cardiology2012

Diuretics and ultrafiltration in acute decompensated heart failure.

G Michael Felker, Robert J Mentz

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of the American College of Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02429388 (High-Dose Aldactone for Treatment of Diuretic Resistant Heart Failure), which is not on this map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02429388 phase4withdrawnnot on this mapstarted 2014, after this paper: background citation

High-Dose Aldactone for Treatment of Diuretic Resistant Heart Failure

TypeinterventionalSponsorThe University of Texas Health Science Center at San AntonioRan2014 to 2015Enrolled0ConditionsHeart FailureArmsSpironolactone
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it, 164 citations in OpenAlex.

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  16. Impact of continuous positive airway pressure on the pulmonary changes promoted by immersion in water.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
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  18. Diuretic Use in Heart Failure.Reviews in cardiovascular medicine · 2025
    Review
  19. Article
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

G Michael FelkerDivision of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA. michael.felker@duke.edu.
Robert J Mentz
Duke University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congestion and volume overload are the hallmarks of acute decompensated heart failure (ADHF), and loop diuretics have historically been the cornerstone of treatment. The demonstrated efficacy of loop diuretics in managing congestion is balanced by the recognized limitations of diuretic resistance, neurohormonal activation, and worsening renal function. However, the recently published DOSE (Diuretic Optimization Strategies Evaluation) trial suggests that previous concerns about the safety of high-dose diuretics may not be valid. There has been a growing interest in alternative strategies to manage volume retention in ADHF with improved efficacy and safety profiles. Peripheral venovenous ultrafiltration (UF) represents a potentially promising approach to volume management in ADHF. Small studies suggest that UF may allow for more effective fluid removal compared with diuretics, with improved quality of life and reduced rehospitalization rates. However, further investigation is needed to completely define the role of UF in patients with ADHF. This review summarizes available data on the use of both diuretics and UF in ADHF patients and identifies challenges and unresolved questions for each approach.

Indexed as

HemofiltrationDopamineDose-Response Relationship, DrugGlomerular Filtration RateHeart FailureHumansMineralocorticoid Receptor AntagonistsSodium Chloride Symporter InhibitorsSodium Potassium Chloride Symporter InhibitorsTreatment OutcomeDopamineMineralocorticoid Receptor AntagonistsSodium Chloride Symporter InhibitorsSodium Potassium Chloride Symporter Inhibitors

Identifiers

PMID22676934
OpenAlexW2137316035

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.