ArticleBMC genomics2012
Comparative analysis of two phenotypically-similar but genomically-distinct Burkholderia cenocepacia-specific bacteriophages.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
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- The dataset on the draft whole-genome sequences of twoData in brief · 2023Article
- Metagenomic comparisons reveal a highly diverse and unique viral community in a seasonally fluctuating hypersaline microbial mat.Microbial genomics · 2023Article
- Synergistic Interactions amongMicrobiology spectrum · 2023Article
- Characterization of Virulent T4-LikeViruses · 2023Article
- Advances in Phage Therapy: Targeting theViruses · 2021Review
- Characterization of Novel Lytic Bacteriophages ofViruses · 2020Article
- Application of a Novel Phage LPSEYT for Biological Control ofMicroorganisms · 2020Article
- Genome Sequences of Five Bacteriophages Infecting the MarineMicrobiology resource announcements · 2018Article
- Evolution of the Quorum network and the mobilome (plasmids and bacteriophages) in clinical strains of Acinetobacter baumannii during a decade.Scientific reports · 2018Article
- Comparative Analysis of 37Viruses · 2017Article
- Identification and analysis of genomic islands in Burkholderia cenocepacia AU 1054 with emphasis on pathogenicity islands.BMC microbiology · 2017Article
- Characterisation and genome sequence of the lytic Acinetobacter baumannii bacteriophage vB_AbaS_Loki.PloS one · 2017Article
- The isolation and characterization of Stenotrophomonas maltophilia T4-like bacteriophage DLP6.PloS one · 2017Article
- Identification and molecular characterization of bacteriophage phiAxp-2 of Achromobacter xylosoxidans.Scientific reports · 2016Article
- Contributions of P2- and P22-like prophages to understanding the enormous diversity and abundance of tailed bacteriophages.Virology · 2016Article
- Isolation and molecular characterisation of Achromobacter phage phiAxp-3, an N4-like bacteriophage.Scientific reports · 2016Article
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3 authors.
Funding
Abstract
backgroundGenomic analysis of bacteriophages infecting the Burkholderia cepacia complex (BCC) is an important preliminary step in the development of a phage therapy protocol for these opportunistic pathogens. The objective of this study was to characterize KL1 (vB_BceS_KL1) and AH2 (vB_BceS_AH2), two novel Burkholderia cenocepacia-specific siphoviruses isolated from environmental samples.
resultsKL1 and AH2 exhibit several unique phenotypic similarities: they infect the same B. cenocepacia strains, they require prolonged incubation at 30°C for the formation of plaques at low titres, and they do not form plaques at similar titres following incubation at 37°C. However, despite these similarities, we have determined using whole-genome pyrosequencing that these phages show minimal relatedness to one another. The KL1 genome is 42,832 base pairs (bp) in length and is most closely related to Pseudomonas phage 73 (PA73). In contrast, the AH2 genome is 58,065 bp in length and is most closely related to Burkholderia phage BcepNazgul. Using both BLASTP and HHpred analysis, we have identified and analyzed the putative virion morphogenesis, lysis, DNA binding, and MazG proteins of these two phages. Notably, MazG homologs identified in cyanophages have been predicted to facilitate infection of stationary phase cells and may contribute to the unique plaque phenotype of KL1 and AH2.
conclusionsThe nearly indistinguishable phenotypes but distinct genomes of KL1 and AH2 provide further evidence of both vast diversity and convergent evolution in the BCC-specific phage population.
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