ReviewPharmacogenomics2012
Next-generation sequencing and large genome assemblies.
Review in Pharmacogenomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed.
- Genome Sequencing and Comparative Transcriptomic Analysis of Rice Brown Spot PathogenJournal of fungi (Basel, Switzerland) · 2025Article
- Rapid identification of antibiotic resistance gene hosts by prescreening ARG-like reads.Environmental science and ecotechnology · 2025Article
- Complete chloroplast genomes of three Polygala species and indel marker development for identification of authentic polygalae radix (Polygala tenuifolia).Genes & genomics · 2025Article
- Complementary approaches to dissect late leaf rust resistance in an interspecific raspberry population.G3 (Bethesda, Md.) · 2024Article
- Ameliorating the effects of multiple stresses on agronomic traits in crops: modern biotechnological and omics approaches.Molecular biology reports · 2023Review
- Review
- Identification and Characterization of a QTL for Growth ofJournal of fungi (Basel, Switzerland) · 2022Article
- Utility of targeted next generation sequencing for inborn errors of immunity at a tertiary care centre in North India.Scientific reports · 2022Article
- A review of the resistome within the digestive tract of livestock.Journal of animal science and biotechnology · 2021Review
- Increasing the power of interpretation for soil metaproteomics data.Microbiome · 2021Article
- Revisiting the methods for detectingAccess microbiology · 2021Review
- In the presence of population structure: From genomics to candidate genes underlying local adaptation.Ecology and evolution · 2020Article
- Review of applications of high-throughput sequencing in personalized medicine: barriers and facilitators of future progress in research and clinical application.Briefings in bioinformatics · 2019Review
- Sequencing-based methods and resources to study antimicrobial resistance.Nature reviews. Genetics · 2019Review
- The Red Fox Y-Chromosome in Comparative Context.Genes · 2019Article
- The first draft genomes of the ant Formica exsecta, and its Wolbachia endosymbiont reveal extensive gene transfer from endosymbiont to host.BMC genomics · 2019Article
- Preimplantation genetic diagnosis and screening (PGD/S) using a semiconductor sequencing platform.Human genomics · 2019Article
- Whole Proteome Clustering of 2,307 Proteobacterial Genomes Reveals Conserved Proteins and Significant Annotation Issues.Frontiers in microbiology · 2019Article
- Article
- Machine Learning for detection of viral sequences in human metagenomic datasets.BMC bioinformatics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The next-generation sequencing (NGS) revolution has drastically reduced time and cost requirements for sequencing of large genomes, and also qualitatively changed the problem of assembly. This article reviews the state of the art in de novo genome assembly, paying particular attention to mammalian-sized genomes. The strengths and weaknesses of the main sequencing platforms are highlighted, leading to a discussion of assembly and the new challenges associated with NGS data. Current approaches to assembly are outlined and the various software packages available are introduced and compared. The question of whether quality assemblies can be produced using short-read NGS data alone, or whether it must be combined with more expensive sequencing techniques, is considered. Prospects for future assemblers and tests of assembly performance are also discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.