ReviewCold Spring Harbor perspectives in medicine2012
Generating β cells from stem cells-the story so far.
Review in Cold Spring Harbor perspectives in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Advanced therapy to cure diabetes: mission impossible is now possible?Frontiers in cell and developmental biology · 2024Review
- Article
- Challenges with Cell-based Therapies for Type 1 Diabetes Mellitus.Stem cell reviews and reports · 2023Review
- PDX1 is the cornerstone of pancreatic β-cell functions and identity.Frontiers in molecular biosciences · 2022Review
- Tailored generation of insulin producing cells from canine mesenchymal stem cells derived from bone marrow and adipose tissue.Scientific reports · 2021Article
- Herbal Medicines Targeting the ImprovedEvidence-based complementary and alternative medicine : eCAM · 2021Review
- The combined effect ofFEBS open bio · 2018Article
- Establishment of Insulin-Producing Cells From Human Embryonic Stem Cells Underhypoxic Condition for Cell Based Therapy.Frontiers in cell and developmental biology · 2018Article
- Article
- Insulin-secreting β cells require a post-genomic concept.World journal of diabetes · 2016Review
- Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation.Cell stem cell · 2016Article
- Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro.The EMBO journal · 2015Article
- Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes.Current pathobiology reports · 2015Article
- Phospho-BAD BH3 mimicry protects β cells and restores functional β cell mass in diabetes.Cell reports · 2015Article
- Pancreatic stem cells remain unresolved.Stem cells and development · 2014Review
- Closing in on pancreatic beta cells.Nature biotechnology · 2014Article
- An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development.PLoS genetics · 2014Article
- Functions and roles of proteins: diabetes as a paradigm.Progress in biophysics and molecular biology · 2014Review
- Macrophage/epithelium cross-talk regulates cell cycle progression and migration in pancreatic progenitors.PloS one · 2014Article
- Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells.eLife · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite intensive research, a treatment for diabetic patients that completely restores normoglycemia for an indefinite period of time remains elusive. Although islet transplantation temporarily confers normoglycemia to patients, the lack of a renewable source of insulin-producing β cells hampers the use of this treatment option. Although significant hurdles remain, recent advances in stem cell biology indicate that generation of fully matured β cells from uncommitted progenitor cells, including human embryonic stem cells and induced pluripotent stem cells derived from somatic cell populations, is becoming an achievable goal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.