ReviewCold Spring Harbor perspectives in medicine2012
Myeloid cells and lymphangiogenesis.
Review in Cold Spring Harbor perspectives in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases.Translational neurodegeneration · 2026Review
- Lymphatic transport in anti-tumor immunity and metastasis.The Journal of experimental medicine · 2025Review
- Functional aspects of the brain lymphatic drainage system in aging and neurodegenerative diseases.Journal of biomedical research · 2024Article
- Myeloid-Derived Lymphatic Endothelial Cell Progenitors Significantly Contribute to Lymphatic Metastasis in Clinical Breast Cancer.The American journal of pathology · 2019Article
- Lymphatic Endothelial Cells Are Essential Components of the Subcapsular Sinus Macrophage Niche.Immunity · 2019Article
- Regulation of Blood and Lymphatic Vessels by Immune Cells in Tumors and Metastasis.Annual review of physiology · 2019Review
- Attenuated Joint Tissue Damage Associated With Improved Synovial Lymphatic Function Following Treatment With Bortezomib in a Mouse Model of Experimental Posttraumatic Osteoarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- Lymphangiogenesis guidance by paracrine and pericellular factors.Genes & development · 2017Review
- Novel role of immature myeloid cells in formation of new lymphatic vessels associated with inflammation and tumors.Journal of leukocyte biology · 2017Review
- Epithelial-mesenchymal transition in cancer metastasis through the lymphatic system.Molecular oncology · 2017Review
- Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4.PloS one · 2017Article
- Efferocytosis and Outside-In Signaling by Cardiac Phagocytes. Links to Repair, Cellular Programming, and Intercellular Crosstalk in Heart.Frontiers in immunology · 2017Review
- Tumor-associated macrophages induce capillary morphogenesis of lymphatic endothelial cells derived from human gastric cancer.Cancer science · 2016Article
- A Critical Role for Monocytes/Macrophages During Intestinal Inflammation-associated Lymphangiogenesis.Inflammatory bowel diseases · 2016Article
- TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer.Oncoimmunology · 2016Article
- Immunological hallmarks of stromal cells in the tumour microenvironment.Nature reviews. Immunology · 2015Review
- Filarial excretory-secretory products induce human monocytes to produce lymphangiogenic mediators.PLoS neglected tropical diseases · 2014Article
- Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors.Oncogene · 2014Article
- Inflammation-associated lymphangiogenesis: a double-edged sword?The Journal of clinical investigation · 2014Review
- Inflammation induces neuro-lymphatic protein expression in multiple sclerosis brain neurovasculature.Journal of neuroinflammation · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lymphatic vascular system and the hematopoietic system are intimately connected in ontogeny and in physiology. During embryonic development, mammalian species derive a first lymphatic vascular plexus from the previously formed anterior cardinal vein, whereas birds and amphibians have a lymphatic vascular system of dual origin, composed of lymphatic endothelial cells (LECs) of venous origin combined with LECs derived from mesenchymal lymphangioblasts. The contribution of hematopoietic cells as building blocks of nascent lymphatic structures in mammals is still under debate. In contrast, the importance of myeloid cells to direct lymphatic vessel growth and function postnatally has been experimentally shown. For example, myeloid cells communicate with LECs via paracrine factors or cell-cell contacts, and they also can acquire lymphatic endothelial morphology and marker gene expression, a process reminiscent of developmental vasculogenesis. Here, we present an overview of the current understanding of how lymphatic vessels and the hematopoietic system, in particular myeloid cells, interact during embryonic development, in normal organ physiology, and in disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.