ArticlePloS one2012
The two-component sensor kinase TcsC and its role in stress resistance of the human-pathogenic mold Aspergillus fumigatus.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 51 citations in OpenAlex.
- Hybrid histidine kinases shape the architecture of the high osmolarity glycerol (HOG) pathway: from Saccharomyces cerevisiae to the priority pathogen Aspergillus fumigatus and other filamentous fungi.FEMS microbiology reviews · 2026Review
- Aspergillus fumigatus escape mechanisms from its harsh survival environments.Applied microbiology and biotechnology · 2024Review
- Adaptative responses of Neurospora crassa by histidine kinases upon the attack of the arthropod Sinella curviseta.Current genetics · 2024Article
- The N-terminus of themBio · 2024Article
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- Longitudinal multimodal imaging-compatible mouse model of triazole-sensitive and -resistant invasive pulmonary aspergillosis.Disease models & mechanisms · 2022Article
- The Role of Dimorphism Regulating Histidine Kinase (Drk1) in the Pathogenic FungusJournal of fungi (Basel, Switzerland) · 2021Article
- Distinct role of HAMP and HAMP-like linker domains in regulating the activity of Hik1p, a hybrid histidine kinase 3 from Magnaporthe oryzae.Molecular genetics and genomics : MGG · 2021Article
- Article
- The response regulator Skn7 of Aspergillus fumigatus is essential for the antifungal effect of fludioxonil.Scientific reports · 2021Article
- A Heterogeneously Expressed Gene Family Modulates the Biofilm Architecture and Hypoxic Growth ofmBio · 2021Article
- Ypd1 Is an Essential Protein of the Major Fungal PathogenFrontiers in fungal biology · 2021Article
- Article
- Stress-Activated Protein Kinases in Human Fungal Pathogens.Frontiers in cellular and infection microbiology · 2019Review
- Analyses of the three 1-Cys Peroxiredoxins from Aspergillus fumigatus reveal that cytosolic Prx1 is central to HScientific reports · 2018Article
- Chemoenzymatic Synthesis, Nanotization, and Anti-Aspergillus Activity of Optically Enriched Fluconazole Analogues.Antimicrobial agents and chemotherapy · 2017Article
- TheFrontiers in microbiology · 2017Article
- The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance.Journal of microbiology (Seoul, Korea) · 2016Review
- Insights into the cellular responses to hypoxia in filamentous fungi.Current genetics · 2015Review
- Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus.Microbiology (Reading, England) · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two-component signaling systems are widespread in bacteria, but also found in fungi. In this study, we have characterized TcsC, the only Group III two-component sensor kinase of Aspergillus fumigatus. TcsC is required for growth under hyperosmotic stress, but dispensable for normal growth, sporulation and conidial viability. A characteristic feature of the ΔtcsC mutant is its resistance to certain fungicides, like fludioxonil. Both hyperosmotic stress and treatment with fludioxonil result in a TcsC-dependent phosphorylation of SakA, the final MAP kinase in the high osmolarity glycerol (HOG) pathway, confirming a role for TcsC in this signaling pathway. In wild type cells fludioxonil induces a TcsC-dependent swelling and a complete, but reversible block of growth and cytokinesis. Several types of stress, such as hypoxia, exposure to farnesol or elevated concentrations of certain divalent cations, trigger a differentiation in A. fumigatus toward a "fluffy" growth phenotype resulting in white, dome-shaped colonies. The ΔtcsC mutant is clearly more susceptible to these morphogenetic changes suggesting that TcsC normally antagonizes this process. Although TcsC plays a role in the adaptation of A. fumigatus to hypoxia, it seems to be dispensable for virulence.
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