ArticlePloS one2012
Selective reduction of AMPA currents onto hippocampal interneurons impairs network oscillatory activity.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Dentate gyrus and CA3 GABAergic interneurons bidirectionally modulate signatures of internal and external drive to CA1.Cell reports · 2021Article
- RippleNet: a Recurrent Neural Network for Sharp Wave Ripple (SPW-R) Detection.Neuroinformatics · 2021Article
- Influence of Prenatal Methamphetamine Abuse on the Brain.Epigenomes · 2020Review
- Age-Dependent Shift of AMPA Receptors From Synapses to Intracellular Compartments in Alzheimer's Disease: Immunocytochemical Analysis of the CA1 Hippocampal Region in APP/PS1 Transgenic Mouse Model.Frontiers in aging neuroscience · 2020Article
- GluA4 Dependent Plasticity Mechanisms Contribute to Developmental Synchronization of the CA3-CA1 Circuitry in the Hippocampus.Neurochemical research · 2019Article
- Presynaptic Effects of N-Methyl-D-Aspartate Receptors Enhance Parvalbumin Cell-Mediated Inhibition of Pyramidal Cells in Mouse Prefrontal Cortex.Biological psychiatry · 2018Article
- Disruption of perineuronal nets increases the frequency of sharp wave ripple events.Hippocampus · 2018Article
- Cognitive deficits caused by prefrontal cortical and hippocampal neural disinhibition.British journal of pharmacology · 2017Review
- NMDA Receptor Expression in the Thalamus of the Stargazer Model of Absence Epilepsy.Scientific reports · 2017Article
- GABAergic Interneurons are Required for Generation of Slow CA1 Oscillation in Rat Hippocampus.Neuroscience bulletin · 2016Article
- Shift in interictal relative gamma power as a novel biomarker for drug response in two mouse models of absence epilepsy.Epilepsia · 2016Article
- Altered Markers of Cortical γ-Aminobutyric Acid Neuronal Activity in Schizophrenia: Role of the NARP Gene.JAMA psychiatry · 2015Article
- Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia.Biological psychiatry · 2015Review
- Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons.Neuron · 2015Article
- Interactions between Inhibitory Interneurons and Excitatory Associational Circuitry in Determining Spatio-Temporal Dynamics of Hippocampal Dentate Granule Cells: A Large-Scale Computational Study.Frontiers in systems neuroscience · 2015Article
- What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GRIA1 (GluA1) AMPA receptor subunit.Molecular psychiatry · 2014Review
- Hippocampal synaptic plasticity, spatial memory and anxiety.Nature reviews. Neuroscience · 2014Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reduction of excitatory currents onto GABAergic interneurons in the forebrain results in impaired spatial working memory and altered oscillatory network patterns in the hippocampus. Whether this phenotype is caused by an alteration in hippocampal interneurons is not known because most studies employed genetic manipulations affecting several brain regions. Here we performed viral injections in genetically modified mice to ablate the GluA4 subunit of the AMPA receptor in the hippocampus (GluA4(HC-/-) mice), thereby selectively reducing AMPA receptor-mediated currents onto a subgroup of hippocampal interneurons expressing GluA4. This regionally selective manipulation led to a strong spatial working memory deficit while leaving reference memory unaffected. Ripples (125-250 Hz) in the CA1 region of GluA4(HC-/-) mice had larger amplitude, slower frequency and reduced rate of occurrence. These changes were associated with an increased firing rate of pyramidal cells during ripples. The spatial selectivity of hippocampal pyramidal cells was comparable to that of controls in many respects when assessed during open field exploration and zigzag maze running. However, GluA4 ablation caused altered modulation of firing rate by theta oscillations in both interneurons and pyramidal cells. Moreover, the correlation between the theta firing phase of pyramidal cells and position was weaker in GluA4(HC-/-) mice. These results establish the involvement of AMPA receptor-mediated currents onto hippocampal interneurons for ripples and theta oscillations, and highlight potential cellular and network alterations that could account for the altered working memory performance.
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