ArticlePloS one2012
Transcriptome profiling of citrus fruit response to huanglongbing disease.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
81 citing papers in PubMed, 3 syntheses or guidelines pooled it, 176 citations in OpenAlex.
- Integrative systems biology analysis of barley transcriptome ─ hormonal signaling against biotic stress.PloS one · 2023Pooled it
- Transcriptomic responses to biotic stresses in Malus x domestica: a meta-analysis study.Scientific reports · 2018Pooled it
- Comprehensive meta-analysis, co-expression, and miRNA nested network analysis identifies gene candidates in citrus against Huanglongbing disease.BMC plant biology · 2015Pooled it
- NPR1 suppresses Candidatus Liberibacter asiaticus-induced callose and reactive oxygen species accumulation.Plant physiology · 2025Article
- Fight smarter, not harder: NPR1-mediated immune balance in citrus greening disease.Plant physiology · 2025Article
- Exploring the Genetic Networks of HLB Tolerance in Citrus: Insights Across Species and Tissues.Plants (Basel, Switzerland) · 2025Article
- Citrus phloem specific transcriptional profiling through the development of a citrus tristeza virus expressed translating ribosome affinity purification system.Plant methods · 2025Article
- Transcriptomic and biochemical analysis of pummelo x finger lime hybrids in response to Huanglongbing (HLB).BMC plant biology · 2025Article
- "Candidatus Liberibacter asiaticus" Infection Induces Citric Acid Accumulation and Immune Responses Mediated by the Transcription Factor CitPH4.Molecular plant pathology · 2025Article
- Early tolerance mechanisms in citrus: transcriptome and hormone profiling of NPR1-mediated responses toFrontiers in plant science · 2025Article
- Transcriptome profile of pecan scab resistant and susceptible trees from a pecan provenance collection.BMC genomics · 2024Article
- Elucidation of mechanisms underlying active oxygen burst inFrontiers in microbiology · 2024Article
- Analysis of huanglongbing-associated RNA-seq data reveals disturbances in biological processes withinFrontiers in plant science · 2024Article
- Gamma-Aminobutyric Acid Supplementation Boosts the Phytohormonal Profile in 'Plants (Basel, Switzerland) · 2023Article
- A gap-free and haplotype-resolved lemon genome provides insights into flavor synthesis and huanglongbing (HLB) tolerance.Horticulture research · 2023Article
- Differential Expression of miRNAs Involved in Response toPlants (Basel, Switzerland) · 2023Article
- Transcriptomic alterations in the sweet orange vasculature correlate with growth repression induced by a variant of citrus tristeza virus.Frontiers in microbiology · 2023Article
- A chromosome-level phased genome enabling allele-level studies in sweet orange: a case study on citrus Huanglongbing tolerance.Horticulture research · 2023Article
- Huanglongbing Pandemic: Current Challenges and Emerging Management Strategies.Plants (Basel, Switzerland) · 2022Review
- Integrated Transcriptome and Metabolome Analysis Reveals Phenylpropanoid Biosynthesis and Phytohormone Signaling Contribute to "International journal of molecular sciences · 2022Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Huanglongbing (HLB) or "citrus greening" is the most destructive citrus disease worldwide. In this work, we studied host responses of citrus to infection with Candidatus Liberibacter asiaticus (CaLas) using next-generation sequencing technologies. A deep mRNA profile was obtained from peel of healthy and HLB-affected fruit. It was followed by pathway and protein-protein network analysis and quantitative real time PCR analysis of highly regulated genes. We identified differentially regulated pathways and constructed networks that provide a deep insight into the metabolism of affected fruit. Data mining revealed that HLB enhanced transcription of genes involved in the light reactions of photosynthesis and in ATP synthesis. Activation of protein degradation and misfolding processes were observed at the transcriptomic level. Transcripts for heat shock proteins were down-regulated at all disease stages, resulting in further protein misfolding. HLB strongly affected pathways involved in source-sink communication, including sucrose and starch metabolism and hormone synthesis and signaling. Transcription of several genes involved in the synthesis and signal transduction of cytokinins and gibberellins was repressed while that of genes involved in ethylene pathways was induced. CaLas infection triggered a response via both the salicylic acid and jasmonic acid pathways and increased the transcript abundance of several members of the WRKY family of transcription factors. Findings focused on the fruit provide valuable insight to understanding the mechanisms of the HLB-induced fruit disorder and eventually developing methods based on small molecule applications to mitigate its devastating effects on fruit production.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.