ArticleEvidence-based complementary and alternative medicine : eCAM2012
Metabolomics-based study of clinical and animal plasma samples in coronary heart disease with blood stasis syndrome.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Multi-Omics Research on Angina Pectoris: A Novel Perspective.Aging and disease · 2024Review
- Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites.Microbial biotechnology · 2022Article
- Effect of diabetes blood-stasis syndrome and Xuefu Zhuyu decoction on ROS-ERK1/2 signaling pathway in rat retina Müller cells.Cytotechnology · 2020Article
- NMR-based plasma metabolic profiling in patients with unstable angina.Iranian journal of basic medical sciences · 2020Article
- Metabolomic analysis of clinical plasma from cerebral infarction patients presenting with blood stasis.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Plasma metabonomics study on Chinese medicine syndrome evolution of heart failure rats caused by LAD ligation.BMC complementary and alternative medicine · 2014Article
- Study on qi deficiency syndrome identification modes of coronary heart disease based on metabolomic biomarkers.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- The Correlation between High-Sensitivity C-Reactive Protein, Matrix Metallopeptidase 9, and Traditional Chinese Medicine Syndrome in Patients with Hypertension.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Detection of urinary metabolomics before and after Pringle maneuver-induced liver ischemia and reperfusion injury in rats using gas chromatography-mass spectrometry.Disease markers · 2013Article
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
The aim of this study is to explore a bridge connecting the mechanism basis and macro syndromes of coronary heart disease with experimental animal models. GC-MS technique was used to detect the metabolites of plasma samples in mini swine models with myocardial infarction (MI) and patients with unstable angina (UA). 30 metabolites were detected in the plasma samples of more than 50 percent of model group and control group in swine, while 37 metabolites were found in the plasma samples of UA patients and healthy control group. 21 metabolites in the plasma samples of swine model and 20 metabolites in patients with UA were found of significant value. Among which, 8 shared metabolites were found of low level expression in both swine model and UA patients. Independent Student's t-test, principal component analysis (PCA), and hierarchicalcluster analysis (HCA) were orderly applied to comprehend inner rules of variables in the data. The 8 shared metabolites could take place of the 21 or 20 metabolites in classification of swine model with MI and UA patients, which could be considered as a bridge connecting the mechanism basis and macrosyndromes of swine model with MI and UA patients.
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Registered trials
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