ArticleExperimental diabetes research2012
Hepatic mitochondrial alterations and increased oxidative stress in nutritional diabetes-prone Psammomys obesus model.
Article in Experimental diabetes research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Impairment of Mitochondrial Respiration in Metabolic Diseases: An Overview.International journal of molecular sciences · 2022Review
- Lipid-Induced Mechanisms of Metabolic Syndrome.Journal of obesity · 2020Review
- Oxidative damage of mitochondrial respiratory chain in different organs of a rat model of diet-induced obesity.European journal of nutrition · 2018Article
- Omega-3 Fatty Acids and Insulin Resistance: Focus on the Regulation of Mitochondria and Endoplasmic Reticulum Stress.Nutrients · 2018Review
- Cardamom powder supplementation prevents obesity, improves glucose intolerance, inflammation and oxidative stress in liver of high carbohydrate high fat diet induced obese rats.Lipids in health and disease · 2017Article
- Article
- A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance.European journal of nutrition · 2016Review
- Protective effects of dietary avocado oil on impaired electron transport chain function and exacerbated oxidative stress in liver mitochondria from diabetic rats.Journal of bioenergetics and biomembranes · 2015Article
- Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action.Molecular metabolism · 2014Article
- Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat.American journal of physiology. Heart and circulatory physiology · 2013Article
- Neuroprotective effect of ginkgolide B on bupivacaine-induced apoptosis in SH-SY5Y cells.Oxidative medicine and cellular longevity · 2013Article
- Article
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7 authors.
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Abstract
Mitochondrial dysfunction is considered to be a pivotal component of insulin resistance and associated metabolic diseases. Psammomys obesus is a relevant model of nutritional diabetes since these adult animals exhibit a state of insulin resistance when fed a standard laboratory chow, hypercaloric for them as compared to their natural food. In this context, alterations in bioenergetics were studied. Using liver mitochondria isolated from these rats fed such a diet for 18 weeks, oxygen consumption rates, activities of respiratory complexes, and content in cytochromes were examined. Levels of malondialdehyde (MDA) and gluthatione (GSH) were measured in tissue homogenates. Diabetic Psammomys showed a serious liver deterioration (hepatic mass accretion, lipids accumulation), accompanied by an enhanced oxidative stress (MDA increased, GSH depleted). On the other hand, both ADP-dependent and uncoupled respirations greatly diminished below control values, and the respiratory flux to cytochrome oxydase was mildly lowered. Furthermore, an inhibition of complexes I and III together with an activation of complex II were found. With emergence of oxidative stress, possibly related to a defect in oxidative phosphorylation, some molecular adjustments could contribute to alleviate, at least in part, the deleterious outcomes of insulin resistance in this gerbil species.
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