ArticleFrontiers in genetics2012
The secret language of destiny: stress imprinting and transgenerational origins of disease.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Sex-dependent biobehavioural responses to transgenerational maternal stress: evidence of stress resilience and vulnerability in the F3 generation.Environmental epigenetics · 2025Article
- Perinatal Psychoneuroimmunology of Prenatal Stress and Its Effects on Fetal and Postnatal Brain Development.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Trans- and Multigenerational Maternal Social Isolation Stress Programs the Blood Plasma Metabolome in the F3 Generation.Metabolites · 2022Article
- Sex-specific stress and biobehavioral responses to human experimenters in rats.Frontiers in neuroscience · 2022Article
- Ancestral stress programs sex-specific biological aging trajectories and non-communicable disease risk.Aging · 2020Article
- The rat cumulative allostatic load measure (rCALM): a new translational assessment of the burden of stress.Environmental epigenetics · 2019Article
- Parental population exposure to historical socioeconomic and political periods and grand-child's birth weight in the Lifeways Cross-Generation Cohort Study in the Republic of Ireland.SSM - population health · 2018Article
- Maternal chromium restriction modulates miRNA profiles related to lipid metabolism disorder in mice offspring.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Characterization of Salt-Induced Epigenetic Segregation by Genome-Wide Loss of Heterozygosity and its Association with Salt Tolerance in Rice (Frontiers in plant science · 2017Article
- Epigenetic memory of oxidative stress: does nephrilin exert its protective effects via Rac1?Biologics : targets & therapy · 2017Article
- Evidence for Ancestral Programming of Resilience in a Two-Hit Stress Model.Frontiers in behavioral neuroscience · 2017Article
- Stress transgenerationally programs metabolic pathways linked to altered mental health.Cellular and molecular life sciences : CMLS · 2016Article
- Environmental Intervention as a Therapy for Adverse Programming by Ancestral Stress.Scientific reports · 2016Article
- Environmental enrichment as an intervention for adverse health outcomes of prenatal stress.Environmental epigenetics · 2016Review
- How to interpret epigenetic association studies: a guide for clinicians.BoneKEy reports · 2016Review
- DNA methylation, early life environment, and health outcomes.Pediatric research · 2016Review
- Allostatic Load and Preterm Birth.International journal of molecular sciences · 2015Review
- Social exclusion changes histone modifications H3K4me3 and H3K27ac in liver tissue of wild house mice.PloS one · 2015Article
- Direct but no transgenerational effects of decitabine and vorinostat on male fertility.PloS one · 2015Article
- A path forward in the debate over health impacts of endocrine disrupting chemicals.Environmental health : a global access science source · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic regulation modulates gene expression without altering the DNA sequence to facilitate rapid adjustments to dynamically changing environmental conditions. The formation of an epigenetic memory allows passing on this information to subsequent generations. Here we propose that epigenetic memories formed by adverse environmental conditions and stress represent a critical determinant of health and disease in the F3 generation and beyond. Transgenerational programming of epigenetic regulation may represent a key to understand adult-onset complex disease pathogenesis and cumulative effects of life span and familial disease etiology. Ultimately, the mechanisms of generating an epigenetic memory may become of potentially promising diagnostic and therapeutic relevance due to their reversible nature. Exploring the role of environmental factors, such as stress, in causing variations in epigenetic profiles may lead to new avenues of personalized, preventive medicine based on epigenetic signatures and interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.