ReviewJournal of biomedicine & biotechnology2012
Oral lichen planus as a preneoplastic inflammatory model.
Review in Journal of biomedicine & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- The Role of Liquid Biopsy in the Diagnosis of Oral Squamous Cell Carcinoma: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Nanotechnology-based drug delivery systems for treatment of oral cancer: a review.International journal of nanomedicine · 2014Pooled it
- Trial
- Oral Lichen Planus and Oral Lichenoid Lesion in Pediatric Patients: A Narrative Review of Published Case Reports.Reports (MDPI) · 2026Review
- Malignant Transformation in Extraoral Lichen Planus: A Systematic Review and Meta-Analysis in the Context of the Risk in Oral Lichen Planus.Dentistry journal · 2026Review
- Impact of non-steroidal anti-inflammatory drugs on malignant transformation in oral lichen planus: insights from a real-world cohort study.Frontiers in pharmacology · 2026Article
- The role of vitamin D deficiency in the development and severity of oral lichen planus: a case-control study.Clinical oral investigations · 2025Article
- Expression of Ki-67 in Oral Lichen Planus: A Systematic Review and Meta-Analysis.Journal of dentistry (Shiraz, Iran) · 2024Review
- Cancer Stem Cell Marker CD147 Expression in Erosive Oral Lichen Planus Compared to Moderately and Severely Dysplastic Leukoplakia.Reports (MDPI) · 2024Article
- Expression of epithelial growth factor receptor as a protein marker in oral reticular and erosive lichen planus.BMC oral health · 2024Article
- Controversies regarding oral lichen planus and lichenoid-dysplastic lesions.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2024Review
- ALDH1 immunoexpression in epithelial and stromal cells of oral lichen planus and lesions with lichenoid inflammatory infiltrate.Medicina oral, patologia oral y cirugia bucal · 2023Article
- Metastases of OSCC Based on Oral Lichen Ruber Planus.Cancers · 2023Article
- A digital score of peri-epithelial lymphocytic activity predicts malignant transformation in oral epithelial dysplasia.The Journal of pathology · 2023Article
- Clinical, histological and direct immunofluorescence features in oral mucosal patches striae diseases with malignant potential.Journal of dental sciences · 2023Article
- The association between high-risk human papillomavirus and oral lichen planus.Clinical and experimental dental research · 2023Article
- Cathepsins in oral diseases: mechanisms and therapeutic implications.Frontiers in immunology · 2023Review
- Oral Squamous Cell Carcinomas Developing from Oral Lichen Planus: A 5-21 year Retrospective Study.Journal of maxillofacial and oral surgery · 2022Article
- Outcome and long-term treatment protocol for topical tacrolimus in oral lichen planus.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Article
- Cathepsin-B and caveolin-1 gene expressions in oral lichen planus and oral squamous cell carcinoma.Molecular biology reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral lichen planus (OLP) is a chronic oral inflammatory disease of unknown etiology. According to reports, 1-2% of OLP patients develop oral squamous cell carcinoma (OSCC) in the long run. While World Health Organization (WHO) classifies OLP as "a potentially malignant disorder," it is still a matter of debate which mechanisms drive OLP to such a condition. The current hypothesis connecting OLP and OSCC is that chronic inflammation results in crucial DNA damage which over time results in cancer development. Initial studies investigating the OLP and OSCC link were mainly retrospective clinical studies. Over the past years, several amount of information has accumulated, mainly from molecular studies on the OLP malignant potential. This article is a critical review of whether OLP has a malignant potential and, therefore, represents a model of preneoplastic inflammation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.