ArticleJournal of clinical microbiology2012
Molecular epidemiology of Aspergillus fumigatus isolates harboring the TR34/L98H azole resistance mechanism.
Article in Journal of clinical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed, 129 citations in OpenAlex.
- Global epidemiology of azole resistance inJAC-antimicrobial resistance · 2026Review
- High prevalence of azole resistance among environmentalFrontiers in microbiology · 2025Article
- A one health roadmap towards understanding and mitigating emerging Fungal Antimicrobial Resistance: fAMR.npj antimicrobials and resistance · 2024Review
- Occurrence of Aspergillus fumigatus azole resistance in soils from Switzerland.Medical mycology · 2023Article
- Genetic structure and triazole resistance amongmSphere · 2023Article
- Citizen science reveals landscape-scale exposures to multiazole-resistantScience advances · 2023Article
- Antifungal resistance, combinations and pipeline: oh my!Drugs in context · 2023Review
- Epidemiology of Clinically SignificantInfection and drug resistance · 2023Article
- A Whole Genome Sequencing-Based Approach to Track down Genomic Variants in Itraconazole-Resistant Species ofJournal of fungi (Basel, Switzerland) · 2022Article
- Genetic Diversity and Azole Resistance Among Natural Aspergillus fumigatus Populations in Yunnan, China.Microbial ecology · 2022Article
- Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment.Nature microbiology · 2022Article
- Phylogenetic Distribution ofMicrobiology spectrum · 2021Article
- Aspergillus fumigatus pan-genome analysis identifies genetic variants associated with human infection.Nature microbiology · 2021Article
- Fungicide effects on human fungal pathogens: Cross-resistance to medical drugs and beyond.PLoS pathogens · 2021Review
- Selection and Amplification of Fungicide Resistance inMicroorganisms · 2021Review
- Review
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- The Consequences of Our Changing Environment on Life Threatening and Debilitating Fungal Diseases in Humans.Journal of fungi (Basel, Switzerland) · 2021Review
- Molecular Epidemiology ofJournal of fungi (Basel, Switzerland) · 2021Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
A rapid emergence of azole resistance has been observed in Aspergillus fumigatus in The Netherlands over the past decade. The dominant resistance mechanism appears to be of environmental origin and involves the TR(34)/L98H mutations in cyp51A. This resistance mechanism is now also increasingly being found in other countries. Therefore, genetic markers were used to gain more insights into the origin and spread of this genotype. Studies of 142 European isolates revealed that those with the TR(34)/L98H resistance mechanism showed less genetic variation than azole-susceptible isolates or those with a different genetic basis of resistance and were assigned to only four CSP (putative cell surface protein) types. Sexual crossing experiments demonstrated that TR(34)/L98H isolates could outcross with azole-susceptible isolates of different genetic backgrounds, suggesting that TR(34)/L98H isolates can undergo the sexual cycle in nature. Overall, our findings suggest a common ancestor of the TR(34)/L98H mechanism and subsequent migration of isolates harboring TR(34)/L98H across Europe.
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