ArticleProceedings of the National Academy of Sciences of the United States of America2012
Water at hydrophobic interfaces delays proton surface-to-bulk transfer and provides a pathway for lateral proton diffusion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Proton wave propagation along collagen fibers.European biophysics journal : EBJ · 2026Article
- Proton Transport as a Missing Design Variable in Immobilized Enzyme Catalysis.Chembiochem : a European journal of chemical biology · 2026Article
- Glycolipids slow interfacial proton migration while preserving surface proton retention.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- ATP synthase activity boosts membrane proton acceptance and lateral diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Bee Venom Proteins Enhance Proton Absorption by Membranes Composed of Phospholipids of the Myelin Sheath and Endoplasmic Reticulum: Pharmacological Relevance.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Calculation of proton transmembrane-electrostatic interaction force and elucidation of the water droplet experiment with a transient protonic front.RSC advances · 2025Article
- Interfacial Microenvironment Effects at Laser-Made Gold Nanoparticles Steer Carbon Dioxide Reduction Product Generation.ACS materials Au · 2025Article
- Multi-proton dynamics near membrane-water interface.Nature communications · 2025Article
- Fluctuating hydrogen-bond network of the Hv1 ion channel.Computational and structural biotechnology journal · 2025Article
- Proton diffusion on the surface of mixed lipid membranes highlights the role of membrane composition.Biophysical journal · 2024Article
- Proton reactions: From basic science to biomedical applications.Biophysical journal · 2024Article
- Spatiotemporal dynamics of the proton motive force on single bacterial cells.Science advances · 2024Article
- Article
- Superprotonic Conductivity of Guanidinium Organosulfonate Hydrogen-Bonded Organic Frameworks with Nanotube-Shaped Proton Transport Channels.Precision chemistry · 2023Article
- A New Theory about Interfacial Proton Diffusion Revisited: The Commonly Accepted Laws of Electrostatics and Diffusion Prevail.Biomolecules · 2023Article
- Article
- Momentum-dependent sum-frequency vibrational spectroscopy of bonded interface layer at charged water interfaces.Science advances · 2023Article
- Proton Migration on Top of Charged Membranes.Biomolecules · 2023Article
- Biomimetic Artificial Proton Channels.Biomolecules · 2022Review
- A critique of the capacitor-based "Transmembrane Electrostatically Localized Proton" hypothesis.Journal of bioenergetics and biomembranes · 2022Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fast lateral proton migration along membranes is of vital importance for cellular energy homeostasis and various proton-coupled transport processes. It can only occur if attractive forces keep the proton at the interface. How to reconcile this high affinity to the membrane surface with high proton mobility is unclear. Here, we tested whether a minimalistic model interface between an apolar hydrophobic phase (n-decane) and an aqueous phase mimics the biological pathway for lateral proton migration. The observed diffusion span, on the order of tens of micrometers, and the high proton mobility were both similar to the values previously reported for lipid bilayers. Extensive ab initio simulations on the same water/n-decane interface reproduced the experimentally derived free energy barrier for the excess proton. The free energy profile G(H(+)) adopts the shape of a well at the interface, having a width of two water molecules and a depth of 6 ± 2RT. The hydroniums in direct contact with n-decane have a reduced mobility. However, the hydroniums in the second layer of water molecules are mobile. Their in silico diffusion coefficient matches that derived from our in vitro experiments, (5.7 ± 0.7) 10(-5) cm(2) s(-1). Conceivably, these are the protons that allow for fast diffusion along biological membranes.
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