ArticleMolecular reproduction and development2012
Developmental expression of the cellular prion protein (PrP(C) ) in bovine embryos.
Article in Molecular reproduction and development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Bovine Spongiform Encephalopathy: An Integrated Review of Prion Mechanisms, Neuroanatomy, and Control.Veterinary sciences · 2026Review
- Detection of prions in oocytes and ovaries of ewes naturally infected with classical scrapie.Veterinary research · 2025Article
- Roles of prion proteins in mammalian development.Animal cells and systems · 2024Review
- Differentially Expressed Candidate miRNAs of Day 16 Bovine Embryos on the Regulation of Pregnancy Establishment in Dairy Cows.Animals : an open access journal from MDPI · 2023Article
- Cellular Prion Protein Is Closely Associated with Early Recurrence and Poor Survival in Patients with Hepatocellular Carcinoma.Diagnostics (Basel, Switzerland) · 2022Article
- Anti-PrP monoclonal antibody as a novel treatment for neurogenesis in mouse model of Alzheimer's disease.Brain and behavior · 2021Article
- Impact of heat stress on embryonic development during first 16 days of gestation in dairy cows.Scientific reports · 2021Article
- mRNA Expressions of Candidate Genes in Gestational Day 16 Conceptus and Corresponding Endometrium in Repeat Breeder Dairy Cows with Suboptimal Uterine Environment Following Transfer of Different Quality Day 7 Embryos.Animals : an open access journal from MDPI · 2021Article
- Article
- What Is Our Current Understanding of PrPPathogens (Basel, Switzerland) · 2017Review
- Physiological Functions of the Cellular Prion Protein.Frontiers in molecular biosciences · 2017Review
- Article
- Prenatal transmission of scrapie in sheep and goats: A case study for veterinary public health.Open veterinary journal · 2016Review
- In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution.Frontiers in neuroscience · 2016Article
- Cellular prion protein promotes post-ischemic neuronal survival, angioneurogenesis and enhances neural progenitor cell homing via proteasome inhibition.Cell death & disease · 2015Article
- In utero transmission and tissue distribution of chronic wasting disease-associated prions in free-ranging Rocky Mountain elk.The Journal of general virology · 2015Article
- Efficient PRNP deletion in bovine genome using gene-editing technologies in bovine cells.Prion · 2015Article
- Prion (PrPC) expression in ovine uteroplacental tissues increases after estrogen treatment of ovariectomized ewes and during early pregnancy.Reproduction (Cambridge, England) · 2014Article
- Article
- Prion protein and aging.Frontiers in cell and developmental biology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The mammalian cellular prion protein (PrP(C) ) is a highly conserved glycoprotein that may undergo conversion into a conformationally altered isoform (scrapie prion protein or PrP(Sc) ), widely believed to be the pathogenic agent of transmissible spongiform encephalopathies (TSEs). Although much is known about PrP(Sc) conversion and its role in TSEs, the normal function of PrP(C) has not been elucidated. In adult mammals, PrP(C) is most abundant in the central nervous tissue, with intermediate levels in the intestine and heart, and lower levels in the pancreas and liver. PrP(C) is expressed during neurogenesis throughout development, and it has recently been proposed that PrP(C) participates in neural cell differentiation during embryogenesis. In order to establish the developmental timing and to address the cell-specific expression of PrP(C) during mammalian development, we examined PrP(C) expression in bovine gametes and embryos through gestation Day 39. Our data revealed differential levels of Prnp mRNA at Days 4 and 18 in pre-attachment embryos. PrP(C) was detected in the developing central and peripheral nervous systems in Day-27, 32-, and -39 embryos. PrP(C) was particularly expressed in differentiated neural cells located in the marginal regions of the central nervous system, but was absent from mitotically active, periventricular areas. Moreover, a PrP(C) cell-specific pattern of expression was detected in non-nervous tissues, including liver and mesonephros, during these stages. The potential participation of PrP(C) in neural cell differentiation is supported by its specific expression in differentiated states of neurogenesis.
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Registered trials
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