Evidence map›Paper›PMID 22674425›Full record

ArticleNMR in biomedicine2013

Feasibility of measuring prostate perfusion with arterial spin labeling.

Xiufeng Li, Gregory J Metzger

Erratum issuedAbstract read
In one paragraph

Article in NMR in biomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

2 authors.

Xiufeng LiCenter for Magnetic Resonance Research, Radiology, University of Minnesota, Minneapolis, MN 55455, USA.
Gregory J Metzger

Funding

ZOOMED FUNCT IMAGING IN HUMAN BRAIN AT 7T W/ SIMULT HIGH SPATIAL &TEMPORAL RESP41RR008079 · NCRR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI VAN DE MOORTELE, PIERRE-FRANCOIS · 1993 to 2011
$16.3M
NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Multi-parametric MRI Determination of Prostate Cancer Aggressiveness and ExtentR01CA131013 · NCI · UNIVERSITY OF MINNESOTA · PI METZGER, GREGORY JOHN · 2008 to 2012
$1.6M
NCI NIH HHS R01 CA131013NCI NIH HHS R01-CA131013NCRR NIH HHS P41 RR008079NIBIB NIH HHS P41 EB015894
6 · The paper itself

Abstract

Prostate perfusion has the potential to become an important pathophysiological marker for the monitoring of disease progression or the assessment of the therapeutic response of prostate cancer. The feasibility of arterial spin labeling, an MRI approach for the measurement of perfusion without an exogenous contrast agent, is demonstrated in the prostate for the first time. Although various arterial spin labeling methods have been demonstrated previously in highly perfused organs, such as the brain and kidneys, the prospect of obtaining such measurements in the prostate is challenging because of the relatively low blood flow, long transit times, susceptibility-induced image distortion and local motion. However, despite these challenges, this study demonstrates that, with a whole-body transmit coil and external receiver array, global prostate perfusion can be measured with arterial spin labeling at 3 T. In five healthy subjects with a mean age of 44 years, the mean total prostate blood flow was measured to be 25.8 ± 7.1 mL/100 cm(3) /min, with an estimated bolus duration and arterial transit time of 884 ± 209 ms and 721 ± 131 ms, respectively.

Indexed as

AlgorithmsAdultBlood Flow VelocityFeasibility StudiesFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance AngiographyMaleProstateReproducibility of ResultsRheologySensitivity and SpecificitySpin LabelsSpin Labels

Identifiers

PMID22674425
PMCPMC3455122

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.