Evidence map›Paper›PMID 22674293›Full record

ArticleCancer causes & control : CCC2012

The association of diabetes with breast cancer incidence and mortality in the Long Island Breast Cancer Study Project.

Rebecca J Cleveland, Kari E North, June Stevens, Susan L Teitelbaum, Alfred I Neugut, Marilie D Gammon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 9 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 9 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
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  10. The Bidirectional Relationship Between Diabetes and Cancer: Mechanistic Insights, Epigenetic Intermediaries, and Therapeutic Approaches.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
    Review
  11. Article
  12. Article
  13. Review
  14. Does diabetes affect breast cancer survival?Cancer reports (Hoboken, N.J.) · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Rebecca J ClevelandDepartment of Medicine, University of North Carolina, Chapel Hill, 27599-7280, USA. becki@unc.edu
Kari E North
June Stevens
Susan L Teitelbaum
Alfred I Neugut
Marilie D Gammon
University of North Carolina at Chapel Hill · USColumbia University · USIcahn School of Medicine at Mount Sinai · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
BREAST CANCER AND THE ENVIRONMENT ON LONG ISLANDU01CA066572 · NCI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI GAMMON, MARILIE D · 1995 to 2004
$1.7M
NCI NIH HHS U01 CA066572NCI NIH HHS UO1CA/ES66572NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30ES10126
6 · The paper itself

Abstract

purposeDiabetes has been associated with increased risk of breast cancer in a number of epidemiologic studies, but its effects on survival among women diagnosed with breast cancer have been examined less frequently. Importantly, prior investigations have rarely considered the influence of factors associated with diabetes such as obesity, age at diabetes diagnosis, duration of diabetes, or diabetes treatments.

methodsWe evaluated the effect of self-reported diabetes on breast cancer incidence and mortality in the Long Island Breast Cancer Study Project, which includes 1,447 breast cancer cases and 1,453 controls. Follow-up data for all-cause (n = 395) and 5-year breast cancer-specific mortality (n = 104) through December 2005 were determined for case women from the National Death Index. Adjusted logistic regression and Cox proportional hazards models were used to estimate odds ratios (OR) and hazards ratios (HR), respectively.

resultsPostmenopausal women with diabetes were at increased risk of developing breast cancer [OR = 1.35; 95 % confidence interval (CI) = 0.99-1.85], as were those who were not of white race regardless of menopausal status [OR = 3.89; 95 % CI = 1.66-9.11]. Among case women, diabetes was associated with a modestly increased risk of death from all causes [HR = 1.65; 95 % CI = 1.18-2.29], an association that was stronger in women who were obese at breast cancer diagnosis [HR = 2.49; 94 % CI = 1.58-3.93]. In analyses restricted to diabetics, there was no statistically significant effect of duration of diabetes or type of treatment on breast cancer incidence or mortality.

conclusionsOur findings suggest that diabetes may increase incidence of breast cancer in older women and non-whites, and mortality due to all causes.

Indexed as

AgedBreast NeoplasmsCase-Control StudiesComorbidityDiabetes MellitusFemaleFollow-Up StudiesHumansIncidenceMiddle AgedNew YorkPopulation SurveillanceProportional Hazards ModelsRisk AssessmentRisk FactorsSurveys and Questionnaires

Identifiers

PMID22674293
PMCPMC3383781
OpenAlexW2128263259

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.