ArticleBioelectromagnetics2013
Electric fields caused by blood flow modulate vascular endothelial electrophysiology and nitric oxide production.
Article in Bioelectromagnetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- High Voltage, High Stakes: Assessing Cardiovascular Effects of Electromagnetic Fields From Electric Vehicles.JACC. Asia · 2026Review
- Electroactive Biomaterials for Cardiovascular Tissue Engineering: Mechanisms, Design Strategies, and Therapeutic Applications.Journal of functional biomaterials · 2026Review
- A review of the evidence to support electrical stimulationRegenerative therapy · 2023Review
- Breaking barriers: exploring mechanisms behind opening the blood-brain barrier.Fluids and barriers of the CNS · 2023Review
- Neuroprotection and Non-Invasive Brain Stimulation: Facts or Fiction?International journal of molecular sciences · 2022Review
- Electric Fields Induced in the Brain by Transcranial Electric Stimulation: A Review of In Vivo Recordings.Biomedicines · 2022Review
- Tissutal and Fluidic Aspects in Osteopathic Manual Therapy: A Narrative Review.Healthcare (Basel, Switzerland) · 2022Review
- Bioelectric Potential in Next-Generation Organoids: Electrical Stimulation to Enhance 3D Structures of the Central Nervous System.Frontiers in cell and developmental biology · 2022Review
- Grey-box modeling and hypothesis testing of functional near-infrared spectroscopy-based cerebrovascular reactivity to anodal high-definition tDCS in healthy humans.PLoS computational biology · 2021Article
- Crosstalk between Bone and Nerves within Bone.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Direct Current Stimulation Disrupts Endothelial Glycocalyx and Tight Junctions of the Blood-Brain BarrierFrontiers in cell and developmental biology · 2021Article
- Current intensity- and polarity-specific online and aftereffects of transcranial direct current stimulation: An fMRI study.Human brain mapping · 2020Article
- In Vivo Modulation of the Blood-Brain Barrier Permeability by Transcranial Direct Current Stimulation (tDCS).Annals of biomedical engineering · 2020Article
- Directional changes in information flow between human brain cortical regions after application of anodal transcranial direct current stimulation (tDCS) over Broca's area.Biomedical optics express · 2018Article
- Transcranial Direct Current Stimulation Modulates Cortical Neuronal Activity in Alzheimer's Disease.Frontiers in neuroscience · 2016Article
- A novel hypothesis for atherosclerosis as a cholesterol sulfate deficiency syndrome.Theoretical biology & medical modelling · 2015Article
- Direct electric stimulation to increase cerebrovascular function.Frontiers in systems neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Endothelial cells are exposed to a ubiquitous, yet unexamined electrical force caused by blood flow: the electrokinetic vascular streaming potential (EVSP). In this study, the hypothesis that extremely low frequency (ELF) electric fields parameterized by the EVSP have significant biological effects on endothelial cell properties was studied by measuring membrane potential and nitric oxide production under ELF stimulation between 0 and 2 Hz and 0-6.67 V/m. Using membrane potential and nitric oxide sensitive fluorescent dyes, bovine aortic endothelial cells (BAECs) in culture were studied in the presence and absence of EVSP-modeled electric fields. The transmembrane potential of BAECs was shown to depolarize between 1 and 7 mV with a strong dependency on both the magnitude and frequency of the isolated ELF field. The findings also support a field interaction with a frequency-dependent tuning curve. The ELF field complexly modulates the nitric oxide response to adenosine triphosphate stimulation with potentiation seen with up to a sevenfold increase. This potentiation was also frequency and magnitude dependent. An early logarithmic phase of NO production is enhanced in a field strength-dependent manner, but the ELF field does not modify a later exponential phase. This study shows that using electric fields on the order of those generated by blood flow influences the essential biology of endothelial cells. The inclusion of ELF electric fields in the paradigm of vascular biology may create novel opportunities for advancing both the understanding and therapies for treatment of vascular diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.