ReviewMolecular neurobiology2012
The brain's response to an essential amino acid-deficient diet and the circuitous route to a better meal.
Review in Molecular neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative effects of intraduodenal amino acid infusions on food intake and gut hormone release in healthy males.Physiological reports · 2017Pooled it
- Brain amino acid sensing for organismal amino acid homeostasis.Open biology · 2025Review
- Article
- Amino Acid-Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Amino acid supplementation counteracts negative effects of low protein diets on tail biting in pigs more than extra environmental enrichment.Scientific reports · 2023Article
- Article
- Two wild carnivores selectively forage for prey but not amino acids.Scientific reports · 2023Article
- Leucine deprivation results in antidepressant effects via GCN2 in AgRP neurons.Life metabolism · 2023Article
- The Origins, Evolution, and Future of Dietary Methionine Restriction.Annual review of nutrition · 2022Review
- Lysine Deprivation Regulates Npy Expression via GCN2 Signaling Pathway in Mandarin Fish (International journal of molecular sciences · 2022Article
- Brain Signaling of Indispensable Amino Acid Deficiency.Journal of clinical medicine · 2021Review
- Protein Appetite Drives Macronutrient-Related Differences in Ventral Tegmental Area Neural Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Diverging metabolic programmes and behaviours during states of starvation, protein malnutrition, and cachexia.Journal of cachexia, sarcopenia and muscle · 2020Review
- Protein intake is more stable than carbohydrate or fat intake across various US demographic groups and international populations.The American journal of clinical nutrition · 2020Article
- Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation.Nature communications · 2020Article
- Sensing and signaling mechanisms linking dietary methionine restriction to the behavioral and physiological components of the response.Frontiers in neuroendocrinology · 2018Review
- Amino acid homeostasis and signalling in mammalian cells and organisms.The Biochemical journal · 2017Review
- Nutrient Sensing: Another Chemosensitivity of the Olfactory System.Frontiers in physiology · 2017Review
- Dietary indispensable amino acids profile affects protein utilization and growth of Senegalese sole larvae.Fish physiology and biochemistry · 2016Article
- Central Amino Acid Sensing in the Control of Feeding Behavior.Frontiers in endocrinology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The essential (indispensable) amino acids (IAA) are neither synthesized nor stored in metazoans, yet they are the building blocks of protein. Survival depends on availability of these protein precursors, which must be obtained in the diet; it follows that food selection is critical for IAA homeostasis. If even one of the IAA is depleted, its tRNA becomes quickly deacylated and the levels of charged tRNA fall, leading to disruption of global protein synthesis. As they have priority in the diet, second only to energy, the missing IAA must be restored promptly or protein catabolism ensues. Animals detect and reject an IAA-deficient meal in 20 min, but how? Here, we review the molecular basis for sensing IAA depletion and repletion in the brain's IAA chemosensor, the anterior piriform cortex (APC). As animals stop eating an IAA-deficient meal, they display foraging and altered choice behaviors, to improve their chances of encountering a better food. Within 2 h, sensory cues are associated with IAA depletion or repletion, leading to learned aversions and preferences that support better food selection. We show neural projections from the APC to appetitive and consummatory motor control centers, and to hedonic, motivational brain areas that reinforce these adaptive behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.