ReviewSub-cellular biochemistry2012
Adherens junctions in C. elegans embryonic morphogenesis.
Review in Sub-cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- PES-8 is required for Cytoskeletal Organization and Contractility in thebioRxiv : the preprint server for biology · 2026Article
- Article
- Intestinal barrier dysfunction: an evolutionarily conserved hallmark of aging.Disease models & mechanisms · 2023Review
- Dual Function of Par3 in Tumorigenesis.Frontiers in oncology · 2022Review
- Genetic Methods for Cellular Manipulation in C. elegans.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Translation-dependent mRNA localization to Caenorhabditis elegans adherens junctions.Development (Cambridge, England) · 2021Article
- Multi-tissue patterning drives anterior morphogenesis of the C. elegans embryo.Developmental biology · 2021Article
- Exposure to dexamethasone modifies transcriptomic responses of free-living stages of Strongyloides stercoralis.PloS one · 2021Article
- Article
- Molecular Effects of Silver Nanoparticles on Monogenean Parasites: Lessons fromInternational journal of molecular sciences · 2020Article
- Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction.Developmental cell · 2019Article
- A high-content imaging approach to profileDevelopment (Cambridge, England) · 2019Article
- Cdc42 regulates junctional actin but not cell polarization in theThe Journal of cell biology · 2017Article
- Article
- Vertebrate Claudin/PMP22/EMP22/MP20 family protein TMEM47 regulates epithelial cell junction maturation and morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Morphogenesis of the C. elegans Intestine Involves Axon Guidance Genes.PLoS genetics · 2016Article
- Occluding junctions of invertebrate epithelia.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Review
- Asymmetric transcript discovery by RNA-seq in C. elegans blastomeres identifies neg-1, a gene important for anterior morphogenesis.PLoS genetics · 2015Article
- Adherens junction distribution mechanisms during cell-cell contact elongation in Drosophila.PloS one · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Caenorhabditis elegans provides a simplified, in vivo model system in which to study adherens junctions (AJs) and their role in morphogenesis. The core AJ components-HMR-1/E-cadherin, HMP-2/β-catenin and HMP-1/α-catenin-were initially identified through genetic screens for mutants with body axis elongation defects. In early embryos, AJ proteins are found at sites of contact between blastomeres, and in epithelial cells AJ proteins localize to the multifaceted apical junction (CeAJ)-a single structure that combines the adhesive and barrier functions of vertebrate adherens and tight junctions. The apically localized polarity proteins PAR-3 and PAR-6 mediate formation and maturation of junctions, while the basolaterally localized regulator LET-413/Scribble ensures that junctions remain apically positioned. AJs promote robust adhesion between epithelial cells and provide mechanical resistance for the physical strains of morphogenesis. However, in contrast to vertebrates, C. elegans AJ proteins are not essential for general cell adhesion or for epithelial cell polarization. A combination of conserved and novel proteins localizes to the CeAJ and works together with AJ proteins to mediate adhesion.
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