Evidence map›Paper›PMID 22674072›Full record

ReviewSub-cellular biochemistry2012

Signaling from the adherens junction.

Abbye E McEwen, David E Escobar, Cara J Gottardi

Abstract readReview
In one paragraph

Review in Sub-cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. The complex relationship of Wnt-signaling pathways and cilia.Current topics in developmental biology · 2023
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Sexual Dimorphism in Colon Cancer.Frontiers in oncology · 2020
    Review
  8. p120-catenin regulates WNT signaling and EMT in the mouse embryo.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. E-cadherin junction formation involves an active kinetic nucleation process.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  18. Nuclear signaling from cadherin adhesion complexes.Current topics in developmental biology · 2015
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Abbye E McEwenThe Integrated Graduate Program in the Life Sciences, Department of Medicine, Northwestern University Feinberg School of Medicine, 60611, Chicago, IL, USA.
David E Escobar
Cara J Gottardi

Funding

Mechanism of nuclear signaling and cell-cell adhesion by cateninsR01GM076561 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOTTARDI, CARA J · 2006 to 2015
$2.8M
The role of E-cadherin phosphorylation in regulating cell-cell adhesionF30CA171944 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCEWEN, ABBYE ELIZABETH · 2013 to 2014
$83k
Alpha catenin phosphorylation in adhesionF31GM101959 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ESCOBAR, DAVID J. · 2013 to 2014
$70k
NCI NIH HHS F30 CA171944NIGMS NIH HHS F31 GM101959NIGMS NIH HHS R01 GM076561
6 · The paper itself

Abstract

The cadherin/catenin complex organizes to form a structural Velcro that joins the cytoskeletal networks of adjacent cells. Functional loss of this complex arrests the development of normal tissue organization, and years of research have gone into teasing out how the physical structure of adhesions conveys information to the cell interior. Evidence that most cadherin-binding partners also localize to the nucleus to regulate transcription supports the view that cadherins serve as simple stoichiometric inhibitors of nuclear signals. However, it is also clear that cadherin-based adhesion initiates a variety of molecular events that can ultimately impact nuclear signaling. This chapter discusses these two modes of cadherin signaling in the context of tissue growth and differentiation.

Indexed as

Signal TransductionAdherens JunctionsAnimalsHumans

Identifiers

PMID22674072
PMCPMC4031758

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.