Evidence map›Paper›PMID 22674017›Full record

ArticleClinical reviews in allergy & immunology2012

Systemic lupus erythematosus, progressive multifocal leukoencephalopathy, and T-CD4+ lymphopenia.

Mariana Brandão, Joana Damásio, António Marinho, Ana Martins da Silva, Júlia Vasconcelos, Esmeralda Neves, Isabel Almeida, Fátima Farinha, Carlos Vasconcelos

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Clinical reviews in allergy & immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Observational
  7. Article
  8. Progressive Multifocal Leukoencephalopathy: Current Insights.Degenerative neurological and neuromuscular disease · 2019
    Review
  9. Article
  10. Review
  11. Immunotherapies for Neurological Manifestations in the Context of Systemic Autoimmunity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016
    Review
  12. Article
  13. Rituximab and lupus--a promising pair?Current rheumatology reports · 2014
    Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mariana BrandãoUnidade de Imunologia Clínica, Department of Medicine, Hospital de Santo António, Centro Hospitalar do Porto, Largo do Professor Abel Salazar, nº 2, 4099-001, Porto, Portugal. mabrsi@gmail.com
Joana Damásio
António Marinho
Ana Martins da Silva
Júlia Vasconcelos
Esmeralda Neves
Isabel Almeida
Fátima Farinha
Carlos Vasconcelos
Centro Hospitalar do Porto · PTHospital de Santo António · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection caused by the reactivation of JC virus and occurs in patients with severe primary or secondary immunosuppression. Recently, PML is becoming relevant in autoimmune disorders, particularly in patients treated with biologic agents. However, systemic lupus erythematosus (SLE) appears to be associated with susceptibility to PML that cannot be entirely explained by the immunosuppressive therapy. The authors present two patients with the diagnosis of SLE and PML: One had a heavy immunosuppressive therapy history, and the other had never experienced biologic or cytotoxic therapeutics. Both patients had a profound T-CD4+ lymphopenia during their clinical history. These two cases emphasize the importance of CD4+ lymphopenia in SLE patients with and without immunosuppressors regarding opportunistic infections.

Indexed as

AdultFemaleHumansImmunosuppressive AgentsLeukoencephalopathy, Progressive MultifocalLupus Erythematosus, SystemicMiddle AgedT-Lymphocytopenia, Idiopathic CD4-PositiveImmunosuppressive Agents

Identifiers

PMID22674017
OpenAlexW1982537301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.