ArticleEuropean journal of immunology2012
The reversible formation of cysteine sulfenic acid promotes B-cell activation and proliferation.
Article in European journal of immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
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- Enhanced mitochondrial fission inhibits triple-negative breast cancer cell migration through an ROS-dependent mechanism.iScience · 2023Article
- Protective effect of acetylcysteine, histidine, and their combination against diabetes vascular complications in type-2 diabetic rats via reducing NF-kβ pathway signaling.Journal of diabetes and metabolic disorders · 2022Article
- SATB1-dependent mitochondrial ROS production controls TCR signaling in CD4 T cells.Life science alliance · 2021Article
- Oxidative stress sensing and response in neural stem cell fate.Free radical biology & medicine · 2021Article
- ROLE OF THIOLS IN OXIDATIVE STRESS.Current opinion in toxicology · 2018Article
- Detecting Protein Sulfenylation in Cells Exposed to a Toxicant.Current protocols in toxicology · 2017Article
- Biological chemistry and functionality of protein sulfenic acids and related thiol modifications.Free radical research · 2016Review
- Au-ACRAMTU-PEt3 Alters Redox Balance To Inhibit T Cell Proliferation and Function.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling.Free radical biology & medicine · 2014Article
- Redox regulation of Janus kinase: The elephant in the room.JAK-STAT · 2013Review
- The redox biochemistry of protein sulfenylation and sulfinylation.The Journal of biological chemistry · 2013Review
- Structure of the catalytic domain of protein tyrosine phosphatase sigma in the sulfenic acid form.Molecules and cells · 2013Article
- Antioxidant treatment regulates the humoral immune response during acute viral infection.Journal of virology · 2013Article
- Increased cell surface free thiols identify effector CD8+ T cells undergoing T cell receptor stimulation.PloS one · 2013Article
- The use of phage display to generate conformation-sensor recombinant antibodies.Nature protocols · 2012Article
- Chemical approaches to detect and analyze protein sulfenic acids.Mass spectrometry reviewsReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
B-cell receptor (BCR) ligation generates reactive oxygen intermediates (ROIs) that play a role in cellular responses. Although ROIs can oxidize all macromolecules, it was unclear which modifications control B-cell responses. In this study, we demonstrate the importance of the first oxidation product of cysteine, sulfenic acid, and its reversible formation in B-cell activation. Upon BCR crosslinking, B cells increase ROI levels with maximal production occurring within 15 min. Increased ROIs preceded elevated cysteine sulfenic acid, which localized to the cytoplasm and nucleus. Analysis of individual proteins revealed that the protein tyrosine phosphatases (PTPs) SHP-1, SHP-2, and PTEN, as well as actin, were modified to sulfenic acid following BCR ligation. Additionally, we used 5,5-dimethyl-1,3-cyclohexanedione (dimedone), a compound that covalently reacts with sulfenic acid to prevent its further oxidation or reduction, to determine the role of reversible cysteine sulfenic acid formation in regulating B-cell responses. Dimedone incubation resulted in a concentration-dependent block in anti-IgM-induced cell division, accompanied by a failure to induce capacitative calcium entry (CCE), and maintain tyrosine phosphorylation. These studies illustrate that reversible cysteine sulfenic acid formation is a mechanism by which B cells modulate pathways critical for activation and proliferation.
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