ArticlePediatric nephrology (Berlin, Germany)2012
Survival and transplantation outcomes of children less than 2 years of age with end-stage renal disease.
Article in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- Mortality Risk Factors among Infants Receiving Dialysis in the Neonatal Intensive Care Unit.The Journal of pediatrics · 2022Article
- Mortality outcomes and clinical background of children on maintenance dialysis without receiving kidney transplantation.Clinical and experimental nephrology · 2022Article
- Serial Amnioinfusion as Regenerative Therapy for Pulmonary Hypoplasia in Fetuses With Intrauterine Renal Failure or Severe Renal Anomalies: Systematic Review and Future Perspectives.Mayo Clinic proceedings. Innovations, quality & outcomes · 2020Article
- Primary causes of kidney disease and mortality in dialysis-dependent children.Pediatric nephrology (Berlin, Germany) · 2020Article
- End-stage kidney disease in infancy: an educational review.Pediatric nephrology (Berlin, Germany) · 2020Review
- Diagnostic and Management Challenges in Congenital Nephrotic Syndrome.Pediatric health, medicine and therapeutics · 2019Review
- Survival in children requiring chronic renal replacement therapy.Pediatric nephrology (Berlin, Germany) · 2018Review
- Management of Denys-Drash syndrome: A case series based on an international survey.Clinical nephrology. Case studies · 2018Article
- Clinical outcomes and survival in pediatric patients initiating chronic dialysis: a report of the NAPRTCS registry.Pediatric nephrology (Berlin, Germany) · 2017Article
- Article
- Timing of renal replacement therapy does not influence survival and growth in children with congenital nephrotic syndrome caused by mutations in NPHS1: data from the ESPN/ERA-EDTA Registry.Pediatric nephrology (Berlin, Germany) · 2016Article
- Prolonged respiratory disorder predicts adverse prognosis in infants with end-stage kidney disease.Pediatric nephrology (Berlin, Germany) · 2016Article
- Chronic haemodialysis in small children: a retrospective study of the Italian Pediatric Dialysis Registry.Pediatric nephrology (Berlin, Germany) · 2016Article
- Long-term hemodialysis therapy in neonates and infants with end-stage renal disease: a 16-year experience and outcome.Pediatric nephrology (Berlin, Germany) · 2016Article
- Factors influencing choice of renal replacement therapy in European paediatric nephrology units.Pediatric nephrology (Berlin, Germany) · 2013Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundYoung children with end-stage renal disease (ESRD) requiring renal replacement therapy (RRT) have traditionally experienced high rates of morbidity and mortality; however, detailed long-term follow-up data is limited.
methodsUsing a population-based retrospective cohort with data from a national organ failure registry and administrative data from Canada's universal health care system, we analysed the outcomes of 87 children starting RRT (before age 2 years) and followed them until death or date of last contact [median follow-up 4.7 years, interquartile range (IQR) 1.4-9.8). We assessed secular trends in survival and the influence of: (1) age at start of RRT and (2) etiology of ESRD with survival and time to transplantation.
resultsPatients were mostly male (69.0 %) with ESRD predominantly due to renal malformations (54.0 %). Peritoneal dialysis was the most common initial RRT (83.9 %). Fifty-seven (65.5 %) children received a renal transplant (median age at first transplant: 2.7 years, IQR 2.0-3.3). During 490 patient-years of follow-up, there were 23 (26.4 %) deaths, of which 22 occurred in patients who had not received a transplant. Mortality was greater for patients commencing dialysis between 1992 and 1999 and among the youngest children starting RRT (0-3 months). Children with ESRD secondary to renal malformations had better survival than those with ESRD due to other causes. Among the transplanted patients, all but one survived to the end of the observation period.
conclusionChildren who start RRT before 3 months of age have a high risk of mortality. Among our paediatric patient cohort, mortality rates were much lower among children who had received a renal transplant.
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