Trial reportJournal of muscle research and cell motility2012
Cytokine and satellite cell responses to muscle damage: interpretation and possible confounding factors in human studies.
Trial report in Journal of muscle research and cell motility, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Effect of Resonant Frequency Vibration on Delayed Onset Muscle Soreness and Resulting Stiffness as Measured by Shear-Wave Elastography.International journal of environmental research and public health · 2021Trial
- Unraveling the bidirectional relationship between muscle inflammation and satellite cells activity: influencing factors and insights.Journal of muscle research and cell motility · 2025Review
- Analysis of plasma-derived small extracellular vesicle characteristics and microRNA cargo following exercise-induced skeletal muscle damage in men.Physiological reports · 2024Article
- Short-term repeated human biopsy sampling contributes to changes in muscle morphology and higher outcome variability.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors.Cell reports · 2023Article
- Elucidating the Pharmacological Properties ofNutrients · 2023Article
- Downhill Running: What Are The Effects and How Can We Adapt? A Narrative Review.Sports medicine (Auckland, N.Z.) · 2020Review
- Review
- Graphene oxide nanofilm and the addition of L-glutamine can promote development of embryonic muscle cells.Journal of nanobiotechnology · 2020Article
- C-Reactive Protein Is Elevated Only in High Creatine Kinase Responders to Muscle Damaging Exercise.Frontiers in physiology · 2019Article
- Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy.Scientific reports · 2018Article
- Investigation of Circulating Extracellular Vesicle MicroRNA Following Two Consecutive Bouts of Muscle-Damaging Exercise.Frontiers in physiology · 2018Article
- Muscle Stem Cell and Physical Activity: What Point is the Debate at?Open medicine (Warsaw, Poland) · 2017Article
- Review
- Evaluation of Muscle Damage Marker after Mixed Martial Arts Matches.Orthopedic reviews · 2016Article
- Regulator Versus Effector Paradigm: Interleukin-10 as Indicator of the Switching Response.Clinical reviews in allergy & immunology · 2016Review
- Skeletal muscle atrophy: disease-induced mechanisms may mask disuse atrophy.Journal of muscle research and cell motility · 2015Review
- The impact of a pre-loaded multi-ingredient performance supplement on muscle soreness and performance following downhill running.Journal of the International Society of Sports Nutrition · 2015Article
- Peripheral cytokines as a chemical mediator for postconcussion like sickness behaviour in trauma and perioperative patients: literature review.Neurology research international · 2014Review
- Acute low-load resistance exercise with and without blood flow restriction increased protein signalling and number of satellite cells in human skeletal muscle.European journal of applied physiology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
It is plausible that multiple muscle biopsies following a muscle damaging intervention can exacerbate the inflammatory and subsequent satellite cell responses. To elucidate confounding effects of muscle biopsy procedure on satellite cell number, indirect markers of damage and the inflammatory response following acute downhill running (DHR) were investigated. 10 healthy male participant were divided into a non-exercising control (n = 4) and DHR (12 × 5min bouts, 10 % decline at 85 % VO(2)max) (n = 6) group. Blood samples were taken pre, post and every 24 h for 9 days. Serum was analysed for creatine kinase (CK), myoglobin (Mb), lactate dehydrogenase (LDH), TNF-α, IL-6 and IL-10. Muscle biopsies taken on days 1 and 2 post intervention from opposing legs were analysed for Pax7(+) satellite cells. In the DHR group, Mb (536 ± 277 ng mL(-1)), IL-6 (12.6 ± 4.7 pg mL(-1)) and IL-10 (27.3 ± 11.5 pg mL(-1)) peaked immediately post DHR, while CK (2651 ± 1911 U L(-1)), LDH (202 ± 47 U L(-1)) and TNF-α (25.1 ± 8.7 pg mL(-1)) peaked on day 1. A 30 % increase in Pax7(+) satellite cells on day 1 in the DHR group was no longer apparent on day 2. H&E staining show evidence of phagocytosis in the DHR group. No significant changes over time were observed in the control group for any of the variables measured. Events observed in the DHR group were as a result of the intervention protocol and subsequent muscle damage. The relationship between SC proliferation and pro-inflammatory cytokine release appears to be complex since the IL-6/IL-10 response time differs significantly from the TNF-α response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.