ArticleEuropean journal of clinical pharmacology2013
Recognition of adverse drug events in older hospitalized medical patients.
Article in European journal of clinical pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Electronic health record-based prediction models for in-hospital adverse drug event diagnosis or prognosis: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2023Pooled it
- Pooled it
- An individual patient data meta-analysis on factors associated with adverse drug events in surgical and non-surgical inpatients.British journal of clinical pharmacology · 2015Pooled it
- The economic burden of inappropriate drug prescribing, lack of adherence and compliance, adverse drug events in older people: a systematic review.Drug safety · 2012Pooled it
- Impact of early in-hospital medication review by clinical pharmacists on health services utilization.PloS one · 2017Trial
- Responsiveness and minimum important change of the Pharmacotherapeutic Symptom Evaluation-20-Australian version: a tool for measuring changes in medicine-related symptoms over time.International journal of clinical pharmacy · 2026Article
- Antiseizure medication discontinuation: A mixed-methods exploration of factors considered by patients when approaching decision-making.Epilepsy research · 2025Article
- Factors influencing central nervous system medication deprescribing and behavior change in hospitalized older adults.Journal of the American Geriatrics Society · 2024Article
- Article
- Jordanians' knowledge, attitude and practice regarding adverse drug reactions reporting.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Automatic Detection of Adverse Drug Events in Geriatric Care: Study Proposal.JMIR research protocols · 2022Article
- Performance of a trigger tool for detecting adverse drug reactions in patients with polypharmacy acutely admitted to the geriatric ward.European geriatric medicine · 2022Article
- Article
- Discrepancy between patient- and healthcare provider-reported adverse drug reactions in inflammatory bowel disease patients on biological therapy.United European gastroenterology journal · 2021Article
- Analytical and Omics-Based Advances in the Study of Drug-Induced Liver Injury.Toxicological sciences : an official journal of the Society of Toxicology · 2021Review
- Preventable adverse drug events causing hospitalisation: identifying root causes and developing a surveillance and learning system at an urban community hospital, a cross-sectional observational study.BMJ open quality · 2021Observational
- Public Awareness about Medicine Information, Safety, and Adverse Drug Reaction (ADR) Reporting in Dammam, Saudi Arabia.Pharmacy (Basel, Switzerland) · 2020Article
- Hyperosmolar dehydration: A predictor of kidney injury and outcome in hospitalised older adults.Clinical nutrition (Edinburgh, Scotland) · 2020Article
- Emergency department-based medication review on outpatient health services utilization: interrupted time series.BMC health services research · 2020Article
- Potential drug-drug interactions associated with clinical and laboratory findings at hospital admission.International journal of clinical pharmacy · 2020Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess medical teams' ability to recognize adverse drug events (ADEs) in older inpatients.
methodsThe study cohort comprised 250 patients aged 65 years or older consecutively admitted to Internal Medicine wards of three hospitals in the Netherlands between April and November 2007. An independent expert team identified ADEs present upon admission or occurring during hospitalization by a structured retrospective patient chart review. For all ADEs identified, the expert team assessed causality, severity, preventability, and recognition by medical teams.
resultsThe medical teams did not recognize 19.9 % of all ADEs present upon admission {60.4 ADEs [95 % confidence interval (CI) 51.5-70.8] per 100 hospitalizations} and 20.3 % of all ADEs occurring during the hospital stay [47.2 ADEs (95 % CI 39.4-56.5) per 100 hospitalizations]. Unrecognized ADEs were significantly more often ADEs with possible causality (p=0.014, df=1), ADEs caused by medication errors (p<0.001, df=1), and ADEs not manifesting as new symptoms (p<0.001, df=1). The medical teams did not recognize 23.2 % of mild to moderately severe ADEs and 16.5 % of severe, life-threatening, or fatal ADEs. The recognition of ADEs varied with event type.
conclusionsThe recognition of ADEs by medical teams was substantial for those ADEs with evident causality and with clinically apparent and severe consequences. ADEs mimicking underlying pathologies with a lower severity went unrecognized much more often, as did those resulting only in abnormal laboratory values. Tools to improve the recognition of ADEs by medical teams should, therefore, focus on those ADEs that are more challenging to detect.
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