ArticleGenome research2012
Effects of ADARs on small RNA processing pathways in C. elegans.
Article in Genome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 61 citations in OpenAlex.
- dsRNAscan maps human dsRNAome, revealing conservation, intermolecular dsRNA, and correlates of ADAR dependency.Molecular cell · 2026Article
- Argonaute-siRNA loading via the RNA-binding protein RDE-4 in C. elegans.Current biology : CB · 2025Article
- Decoding microRNA arm switching: a key to evolutionary innovation and gene regulation.Cellular and molecular life sciences : CMLS · 2025Review
- Comprehensive Mapping of Human dsRNAome Reveals Conservation, Neuronal Enrichment, and Intermolecular Interactions.bioRxiv : the preprint server for biology · 2025Article
- A low-abundance class of Dicer-dependent siRNAs produced from a variety of features inGenome research · 2024Article
- The competitive landscape of the dsRNA world.Molecular cell · 2024Review
- ADAR-mediated regulation of PQM-1 expression in neurons impacts gene expression throughout C. elegans and regulates survival from hypoxia.PLoS biology · 2023Article
- EpisomiR, a New Family of miRNAs, and Its Possible Roles in Human Diseases.Biomedicines · 2022Review
- To protect and modify double-stranded RNA - the critical roles of ADARs in development, immunity and oncogenesis.Critical reviews in biochemistry and molecular biology · 2021Review
- miRNA-Based Therapeutics in the Era of Immune-Checkpoint Inhibitors.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Modulating microRNA Processing: Enoxacin, the Progenitor of a New Class of Drugs.Journal of medicinal chemistry · 2020Article
- PhenoMIP: High-Throughput Phenotyping of DiverseG3 (Bethesda, Md.) · 2020Article
- RNA editing in mesothelioma: a look forward.Open biology · 2020Review
- mRNA Editing, Processing and Quality Control inGenetics · 2020Review
- Article
- Deciphering miRNAs' Action through miRNA Editing.International journal of molecular sciences · 2019Review
- henn-1/HEN1 Promotes Germline Immortality in Caenorhabditis elegans.Cell reports · 2019Article
- DOT1L complex suppresses transcription from enhancer elements and ectopic RNAi inRNA (New York, N.Y.) · 2019Article
- Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing.Cell reports · 2019Article
- Mapping the dsRNA World.Cold Spring Harbor perspectives in biology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Adenosine deaminases that act on RNA (ADARs) are RNA editing enzymes that convert adenosine to inosine in double-stranded RNA (dsRNA). To evaluate effects of ADARs on small RNAs that derive from dsRNA precursors, we performed deep-sequencing, comparing small RNAs from wild-type and ADAR mutant Caenorhabditis elegans. While editing in small RNAs was rare, at least 40% of microRNAs had altered levels in at least one ADAR mutant strain, and miRNAs with significantly altered levels had mRNA targets with correspondingly affected levels. About 40% of siRNAs derived from endogenous genes (endo-siRNAs) also had altered levels in at least one mutant strain, including 63% of Dicer-dependent endo-siRNAs. The 26G class of endo-siRNAs was significantly affected by ADARs, and many altered 26G loci had intronic reads and histone modifications associated with transcriptional silencing. Our data indicate that ADARs, through both direct and indirect mechanisms, are important for maintaining wild-type levels of many small RNAs in C. elegans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.