ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2012
Group IVA phospholipase A₂ optimizes ovulation and fertilization in rodents through induction of and metabolic coupling with prostaglandin endoperoxide synthase 2.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- The Phospholipase AJournal of lipid and atherosclerosis · 2026Review
- Article
- Autophagy in the corpus luteum correlates with tissue growth in pregnant rats.The Journal of reproduction and development · 2024Article
- Transcriptomic comparison of ovarian granulosa cells between adult sheep and prepubertal lambs.BMC genomics · 2022Article
- Protein Kinase A and 5' AMP-Activated Protein Kinase Signaling Pathways Exert Opposite Effects on Induction of Autophagy in Luteal Cells.Frontiers in cell and developmental biology · 2021Article
- Identification of new progestogen-associated networks in mammalian ovulation using bioinformatics.BMC systems biology · 2018Article
- In vivo evidence for possible up-regulating roles of lysophosphatidic acid around fertilization in rats.The Journal of veterinary medical science · 2018Article
- Early transcriptome responses of the bovine midcycle corpus luteum to prostaglandin F2α includes cytokine signaling.Molecular and cellular endocrinology · 2017Article
- Possible role of PPARγ in the negative regulation of ovulatory cascade and luteal development in rats.The Journal of veterinary medical science · 2017Article
- Cytosolic phospholipase A₂: physiological function and role in disease.Journal of lipid research · 2015Review
- American ginseng regulates gene expression to protect against premature ovarian failure in rats.BioMed research international · 2015Article
- A genome-wide association study in large white and landrace pig populations for number piglets born alive.PloS one · 2015Article
- Novel contraceptive targets to inhibit ovulation: the prostaglandin E2 pathway.Human reproduction updateReview
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Female mice lacking group IVA phospholipase A(2) (Pla2g4a(-/-)) have a smaller litter size, which is due, in part, to defective implantation. We examined PLA(2)G4A dependence of the processes of ovulation and fertilization. Following induction of ovulation by equine chorionic gonadotropin (eCG)/human CG (hCG) treatment and mating, ovulation and fertilization rates were reduced significantly in Pla2g4a(-/-) mice as compared to wild-type littermates. Human CG triggered robust ovarian prostaglandin (PG) E(2) production in the preovulatory period that was significantly attenuated in Pla2g4a(-/-) mice. Human CG transiently enhanced ovarian expression of PLA(2)G4A and prostaglandin endoperoxide synthase 2 (PTGS2) in wild-type mice. This PTGS2 induction was decreased in Pla2g4a(-/-) mice and also in immature rats treated with the PLA(2)G4A inhibitor, archidonyl trifluoromethyl ketone. A close spatiotemporal association of PLA(2)G4A with PTGS2 was found in mouse and rat preovulatory follicles examined by immunohistochemistry. Less association was observed with 4 other forms of PLA(2). Our data strongly suggest that PLA(2)G4A amplifies hCG induction of PTGS2 and colocalizes with the induced PTGS2, thus contributing to robust PG production required for optimal ovulation and fertilization in rodents.
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Registered trials
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