ArticleJournal of neurophysiology2012
Skin incision-induced receptive field responses of mechanosensitive peripheral neurons are developmentally regulated in the rat.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
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- The Development of Nociceptive Network Activity in the Somatosensory Cortex of Freely Moving Rat Pups.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Nerve injury induced activation of fast-conducting high threshold mechanoreceptors predicts non-reflexive pain related behavior.Neuroscience letters · 2016Article
- Mechanical sensibility of nociceptive and non-nociceptive fast-conducting afferents is modulated by skin temperature.Journal of neurophysiology · 2016Article
- Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents.Journal of neurophysiology · 2015Article
- Age-dependent sensitization of cutaneous nociceptors during developmental inflammation.Molecular pain · 2014Article
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Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Maturation of the nervous system results in changes in both central and peripheral processing. To better understand responses to injury in the young, developmental differences in the acute response to incision were investigated in both tactile and nociceptive myelinated peripheral mechanosensitive afferent neurons in vivo. Neuronal intrasomal recordings were performed in juvenile and infant rats in 34 L5 dorsal root ganglia, and each neuron was phenotypically defined. Neurons had a mechanosensitive receptive field in the glabrous skin on the plantar surface of the hind paw, which was characterized at baseline and for up to 45 min after incision. Fundamental maturational differences in the effect of incision were clear: in high-threshold nociceptive mechanoreceptors, the mechanical threshold decreased immediately and the receptive field size increased rapidly in juvenile rats but not in infant rats. Additionally, a divergence in changes in the instantaneous response frequency of tactile afferents occurred between the two ages. These differences may help explain maturational differences in responses to peripheral injury and suggest that differences in central nervous system responses may be partially mitigated by spatially confined and frequency-dependent differences resulting from tactile and nociceptive mechanosensitive input.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.