ArticleGenes and immunity2012
Genome-wide association study identifies common variants at TNFRSF13B associated with IgG level in a healthy Chinese male population.
Article in Genes and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Determinants of Serum Immunoglobulin Levels: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2021Pooled it
- Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.Genome medicine · 2018Trial
- The Myeloma Risk Variant of TNFRSF13B Shows Reduced NF-κB Signalling Activity in HEK293 Cells.European journal of haematology · 2026Article
- Total Immunoglobulin G Variation Through the Phenological Cycle of Migrant and Resident Lesser Long-Nosed Bats (Leptonycteris yerbabuenae) in the Drylands of Mexico and Its Relationship With Bacterial Killing-Ability of Plasma.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Deciphering the genetics and mechanisms of predisposition to multiple myeloma.Nature communications · 2024Article
- Determinants and Reference Ranges of Serum Immunoglobulins in Middle-Aged and Elderly Individuals: a Population-Based Study.Journal of clinical immunology · 2021Article
- TACI haploinsufficiency protects against BAFF-driven humoral autoimmunity in mice.European journal of immunology · 2021Article
- Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups.Nature communications · 2021Article
- Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults.Genome medicine · 2020Article
- Identification of sequence variants influencing immunoglobulin levels.Nature genetics · 2017Article
- IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.Human molecular genetics · 2014Article
- Quantitative genetics in the study of virus-induced disease.Advances in virus research · 2014Review
- Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.Nature genetics · 2013Article
- Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers.Immunogenetics · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IgG has a crucial role in humoral immune response. Serum IgG level is mainly determined under genetic control. To explore the genetic influence on serum IgG levels, a two-stage genome-wide association study (GWAS) was performed in a healthy Chinese population of 3495 men, including 1999 unrelated subjects in the first stage and 1496 independent individuals in the second stage. Three single-nucleotide polymorphisms (SNPs) located in TNFRSF13B on 17p11.2 or nearby were significantly associated with IgG level: rs4792800 in the intron (combined P-value=1.45 × 10(-12)), rs12603708 in the intron (combined P-value=1.82 × 10(-8)) and rs3751987 at ~65 kb downstream of the 5'-UTR region of TNFRSF13B (combined P-value=3.67 × 10(-9)). Additionally, smoking was identified to be associated with IgG level in both stages (P<0.001), but there was no significant interaction between smoking and the identified SNPs (P>0.05). The strong association between variants at TNFRSF13B and IgG level may be helpful to further explore the biological mechanism by which the serum IgG is affected by transmembrane activator, calcium modulator and cyclophilin ligand interactor encoded by TNFRSF13B.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.